UniProt Accession

 B7Z3C7_HUMAN; B7Z3C7 

Genbank Protein ID

 AL135783; AL683813; AK295709 

Genbank Nucleotide ID

 BAH12163.1 

Protein Name

 Rho guanine nucleotide exchange factor 6 

Protein Synonyms/Alias

 cDNA FLJ50776, highly similar to Rho guanine nucleotide exchange factor 6 

Gene Name

 ARHGEF6 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
103	PLSPKAVKGFETAPL	ubiquitination	[1]
255	KPFMRLEKYVTLLQE	ubiquitination	[1]
368	SGFIYQGKIPIAGTV	ubiquitination	[1]
431	ASCSSLSKTSSSSCS	ubiquitination	[1, 2, 3]
490	ERMSYILKESSKSPK	ubiquitination	[1]
511	HKRKTERKPSEEEYV	ubiquitination	[1]
534	EEDAQILKVIEAYCT	ubiquitination	[1]
555	GHGSSTRKDSIPQVL	ubiquitination	[1, 3]
568	VLLPEEEKLIIEETR	ubiquitination	[1, 3]
585	GQTIMEEKSLVDTVY	ubiquitination	[1]
595	VDTVYALKDEVRELK	ubiquitination	[1, 2, 3]
609	KQENKRMKQCLEEEL	ubiquitination	[1, 3]
631	KLVRRLLKQTDECIR	ubiquitination	[1, 3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 649 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. 

Interpro

 IPR000219; DH-domain.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR011511; SH3_2.
 IPR001452; SH3_domain. 

Pfam

 PF00169; PH
 PF00621; RhoGEF
 PF07653; SH3_2 

SMART

 SM00233; PH
 SM00325; RhoGEF
 SM00326; SH3 

PROSITE

 PS50010; DH_2
 PS50003; PH_DOMAIN
 PS50002; SH3 

PRINTS

 PR00452; SH3DOMAIN.