| Tag | Content |
|---|
| CPLM ID | CPLM-016578 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein NDRG4 |
Protein Synonyms/Alias | N-myc downstream-regulated gene 4 protein; Protein Ndr4 |
Gene Name | Ndrg4 |
Gene Synonyms/Alias | Kiaa1180; Ndr4 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 79 | VVIRGSPKGNRPAIL | ubiquitination | [1] | | 275 | PGTVPNAKTLRCPVM | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress. May enhance growth factor- induced ERK1 and ERK2 phosphorylation. May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner. |
Sequence Annotation | MOD_RES 298 298 Phosphoserine. |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 352 AA |
Protein Sequence | MKVLGHRLQL LTGLLLHDVT MAGLQELRFP EEKPLLRGQD ATEMDNPDAF LSIVDTDWKE 60
HDIETPYGLL HVVIRGSPKG NRPAILTYHD VGLNHKLCFN TFFNFEDMQE ITKHFVVCHV 120
DAPGQQVGAS QFPQGYQFPS MEQLAAMLPS VVQHFGFKYV IGIGVGAGAY VLAKFALIFP 180
DLVEGLVLMN IDPNGKGWID WAATKLSGLT STLPDTVLSH LFSQEELVNN TELVQSYRQQ 240
ISNVVNQANL QLFWNMYNSR RDLDINRPGT VPNAKTLRCP VMLVVGDNAP AEEGVVECNS 300
KLDPTTTTFL KMADSGGLPQ VTQPGKLTEA FKYFLQGMGY IAHLKDRRLS GGAVPSASMT 360
RLARSRTASL TSASSVDGSR PQPCAHSDSS EGMGQVNHTM EVSC 404 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |