| Tag | Content |
|---|
| CPLM ID | CPLM-022294 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | NACHT, LRR and PYD domains-containing protein 2 |
Protein Synonyms/Alias | Nucleotide-binding site protein 1; PYRIN domain and NACHT domain-containing protein 1; PYRIN-containing APAF1-like protein 2 |
Gene Name | NLRP2 |
Gene Synonyms/Alias | NALP2; NBS1; PAN1; PYPAF2 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 128 | DEMLERFKTEAQAFT | ubiquitination | [1] | | 567 | LANEKRAKELEATFG | ubiquitination | [1] | | 659 | KMSLQVIKENLPENV | ubiquitination | [1] | | 1037 | LLEEIEEKNPQLIID | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases. |
Sequence Annotation | DOMAIN 1 94 DAPIN.
DOMAIN 207 526 NACHT.
REPEAT 812 832 LRR 1.
REPEAT 841 861 LRR 2.
REPEAT 869 889 LRR 3.
REPEAT 898 918 LRR 4.
REPEAT 926 946 LRR 5.
REPEAT 955 976 LRR 6.
REPEAT 983 1003 LRR 7.
REPEAT 1010 1033 LRR 8.
NP_BIND 213 220 ATP (Potential).
MOD_RES 671 671 Phosphoserine. |
Keyword | Alternative splicing; Apoptosis; ATP-binding; Complete proteome; Cytoplasm; Leucine-rich repeat; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1062 AA |
Protein Sequence | MVSSAQMGFN LQALLEQLSQ DELSKFKYLI TTFSLAHELQ KIPHKEVDKA DGKQLVEILT 60
THCDSYWVEM ASLQVFEKMH RMDLSERAKD EVREAALKSF NKRKPLSLGI TRKERPPLDV 120
DEMLERFKTE AQAFTETKGN VICLGKEVFK GKKPDKDNRC RYILKTKFRE MWKSWPGDSK 180
EVQVMAERYK MLIPFSNPRV LPGPFSYTVV LYGPAGLGKT TLAQKLMLDW AEDNLIHKFK 240
YAFYLSCREL SRLGPCSFAE LVFRDWPELQ DDIPHILAQA RKILFVIDGF DELGAAPGAL 300
IEDICGDWEK KKPVPVLLGS LLNRVMLPKA ALLVTTRPRA LRDLRILAEE PIYIRVEGFL 360
EEDRRAYFLR HFGDEDQAMR AFELMRSNAA LFQLGSAPAV CWIVCTTLKL QMEKGEDPVP 420
TCLTRTGLFL RFLCSRFPQG AQLRGALRTL SLLAAQGLWA QTSVLHREDL ERLGVQESDL 480
RLFLDGDILR QDRVSKGCYS FIHLSFQQFL TALFYTLEKE EEEDRDGHTW DIGDVQKLLS 540
GVERLRNPDL IQAGYYSFGL ANEKRAKELE ATFGCRMSPD IKQELLRCDI SCKGGHSTVT 600
DLQELLGCLY ESQEEELVKE VMAQFKEISL HLNAVDVVPS SFCVKHCRNL QKMSLQVIKE 660
NLPENVTASE SDAEVERSQD DQHMLPFWTD LCSIFGSNKD LMGLAINDSF LSASLVRILC 720
EQIASDTCHL QRVVFKNISP ADAHRNLCLA LRGHKTVTYL TLQGNDQDDM FPALCEVLRH 780
PECNLRYLGL VSCSATTQQW ADLSLALEVN QSLTCVNLSD NELLDEGAKL LYTTLRHPKC 840
FLQRLSLENC HLTEANCKDL AAVLVVSREL THLCLAKNPI GNTGVKFLCE GLRYPECKLQ 900
TLVLWNCDIT SDGCCDLTKL LQEKSSLLCL DLGLNHIGVK GMKFLCEALR KPLCNLRCLW 960
LWGCSIPPFS CEDLCSALSC NQSLVTLDLG QNPLGSSGVK MLFETLTCSS GTLRTLRLKI 1020
DDFNDELNKL LEEIEEKNPQ LIIDTEKHHP WAERPSSHDF MI 1062 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:HGNC. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:HGNC. GO:0050718; P:positive regulation of interleukin-1 beta secretion; IDA:HGNC. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |