UniProt Accession

 B4DDG6_HUMAN; B4DDG6 

Genbank Protein ID

 AL592300; AK293186; CH471067 

Genbank Nucleotide ID

 BAG56727.1; EAW91401.1 

Protein Name

 Protein tyrosine phosphatase, non-receptor type 7, isoform CRA_b 

Protein Synonyms/Alias

 Tyrosine-protein phosphatase non-receptor type 7; cDNA FLJ60410, highly similar to Tyrosine-protein phosphatase non-receptor type7 (EC 3.1.3.48) 

Gene Name

 PTPN7 

Gene Synonyms/Alias

 hCG_31786 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
32	QLREGKEKCVHYWPT	ubiquitination	[1, 2]
55	QIRIQDMKECPEYTV	ubiquitination	[1, 2, 3]
77	QEERRSVKHILFSAW	ubiquitination	[1]
141	RIGCQQLKARGEVDI	ubiquitination	[1, 2, 3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Hydrolase; Protein phosphatase; Receptor; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 189 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:Compara.
 GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
 GO:0035335; P:peptidyl-tyrosine dephosphorylation; IEA:GOC. 

Interpro

 IPR000387; Tyr/Dual-sp_Pase.
 IPR016130; Tyr_Pase_AS.
 IPR008356; Tyr_Pase_KIM-con.
 IPR000242; Tyr_Pase_rcpt/non-rcpt. 

Pfam

 PF00102; Y_phosphatase 

SMART

 SM00194; PTPc 

PROSITE

 PS00383; TYR_PHOSPHATASE_1
 PS50056; TYR_PHOSPHATASE_2
 PS50055; TYR_PHOSPHATASE_PTP 

PRINTS

 PR01778; KIMPTPASE.
 PR00700; PRTYPHPHTASE.