UniProt Accession

 E7ESB4_HUMAN; E7ESB4 

Genbank Protein ID

 AL160282 

Genbank Nucleotide ID

  

Protein Name

 E3 SUMO-protein ligase PIAS3 

Protein Synonyms/Alias

  

Gene Name

 PIAS3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
47	CAPSVQMKIKELYRR	ubiquitination	[1]
174	REVLPGAKCDYTIQV	ubiquitination	[1]
227	TKNGAEPKRPSRPIN	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 259 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0030425; C:dendrite; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0045202; C:synapse; IEA:Compara.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0015459; F:potassium channel regulator activity; IEA:Compara.
 GO:0019789; F:SUMO ligase activity; IEA:Compara.
 GO:0010628; P:positive regulation of gene expression; IEA:Compara.
 GO:0045838; P:positive regulation of membrane potential; IEA:Compara.
 GO:0016925; P:protein sumoylation; IEA:Compara.
 GO:0009725; P:response to hormone stimulus; IEA:Compara. 

Interpro

 IPR027226; PIAS3.
 IPR023321; PINIT.
 IPR003034; SAP_dom. 

Pfam

 PF14324; PINIT 

SMART

 SM00513; SAP 

PROSITE

 PS51466; PINIT
 PS50800; SAP 

PRINTS