CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008100
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial 
Protein Synonyms/Alias
 Ubiquinone biosynthesis methyltransferase COQ5 
Gene Name
 COQ5 
Gene Synonyms/Alias
 DBI56; YML110C; YM8339.09C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
182FLVSNGEKLEEIDSDacetylation[1]
208RNFTDIQKGLNTAYRacetylation[1]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
 Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). 
Sequence Annotation
  
Keyword
 Complete proteome; Methyltransferase; Mitochondrion; Reference proteome; Transferase; Transit peptide; Ubiquinone biosynthesis. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 307 AA 
Protein Sequence
MLISSRIVRS SLVNVPLRLS RCFTQAHRAC KEEEVNSPLS SAAEQPEQKY THFGSKTVLK 60
STKQKLVGDV FSSVANRYDL MNDVMSLGIH RLWKDHFINK LDAGKRPNST TPLNFIDVAG 120
GSGDIAFGLL DHAESKFGDT ESTMDIVDIN PDMLKEGEKR AMEQGKYFKD PRVRFLVSNG 180
EKLEEIDSDS KDIYTVSFGI RNFTDIQKGL NTAYRVLKPG GIFYCLEFSK IENPLMDFAY 240
QQWAKVLPVM GSMIANDYDS YQYLVESIER FPDQETFKSM IEKAGFKSAG YESLTFGICA 300
IHWGIKV 307 
Gene Ontology
 GO:0005759; C:mitochondrial matrix; IDA:SGD.
 GO:0043334; F:2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity; IMP:SGD.
 GO:0009060; P:aerobic respiration; IMP:SGD.
 GO:0006744; P:ubiquinone biosynthetic process; IMP:SGD. 
Interpro
 IPR004033; UbiE/COQ5_MeTrFase.
 IPR023576; UbiE/COQ5_MeTrFase_CS.
 IPR025765; UbiE/COQ5_MeTrFase_dom. 
Pfam
 PF01209; Ubie_methyltran 
SMART
  
PROSITE
 PS01183; UBIE_1
 PS01184; UBIE_2 
PRINTS