UniProt Accession

 TNNI2_MOUSE; P13412; A2A6J9 

Genbank Protein ID

 J04992; AL603651; BC028515 

Genbank Nucleotide ID

 AAA40485.1; CAM23286.1; AAH28515.1 

Protein Name

 Troponin I, fast skeletal muscle 

Protein Synonyms/Alias

 Troponin I, fast-twitch isoform 

Gene Name

 Tnni2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
32	IAATELEKEESRRES	ubiquitination	[1]
66	SEVQELCKQLHAKID	ubiquitination	[1]
79	IDVAEEEKYDMEVKV	ubiquitination	[1]
85	EKYDMEVKVQKSSKE	ubiquitination	[1]
91	VKVQKSSKELEDMNQ	ubiquitination	[1]
99	ELEDMNQKLFDLRGK	ubiquitination	[1]
124	MSADAMLKALLGSKH	ubiquitination	[1]
130	LKALLGSKHKVCMDL	ubiquitination	[1]
132	ALLGSKHKVCMDLRA	ubiquitination	[1]
168	WRKNIEEKSGMEGRK	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. 

Sequence Annotation

 REGION 2 48 Involved in binding TNC.
 REGION 97 117 Involved in binding TNC and actin.
 MOD_RES 2 2 N-acetylglycine (By similarity).
 MOD_RES 12 12 Phosphothreonine (By similarity).
 MOD_RES 118 118 Phosphoserine (By similarity).  

Keyword

 Acetylation; Actin-binding; Calcium; Complete proteome; Metal-binding; Muscle protein; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 182 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:Compara.
 GO:0005861; C:troponin complex; IEA:Compara.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0003009; P:skeletal muscle contraction; IEA:Compara. 

Interpro

 IPR001978; Troponin. 

Pfam

 PF00992; Troponin 

SMART

  

PROSITE

  

PRINTS