UniProt Accession

 EFNB1_MOUSE; P52795 

Genbank Protein ID

 U07602; U07598; U07599; U07600; Z48781; U12983; BC006797; BC021656 

Genbank Nucleotide ID

 AAC53247.1; AAC53247.1; AAC53247.1; AAC53247.1; CAA88695.1; AAA53231.1; AAH06797.1; AAH21656.1 

Protein Name

 Ephrin-B1 

Protein Synonyms/Alias

 CEK5 receptor ligand; CEK5-L; ELK ligand; ELK-L; EPH-related receptor tyrosine kinase ligand 2; LERK-2; Stimulated by retinoic acid gene 1 protein 

Gene Name

 Efnb1 

Gene Synonyms/Alias

 Epl2; Eplg2; Lerk2; Stra1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
288	LSTLASPKGGSGTAG	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to the receptor tyrosine kinases EPHB3 (preferred), EPHB1 and EPHA1. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons. 

Sequence Annotation

 DOMAIN 30 164 Ephrin RBD.
 MOTIF 343 345 PDZ-binding (Potential).
 MOD_RES 286 286 Phosphoserine.
 CARBOHYD 139 139 N-linked (GlcNAc...) (Potential).
 DISULFID 64 101 By similarity.
 DISULFID 89 153 By similarity.  

Keyword

 Complete proteome; Developmental protein; Differentiation; Disulfide bond; Glycoprotein; Membrane; Neurogenesis; Phosphoprotein; Reference proteome; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 345 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0045121; C:membrane raft; IDA:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0007411; P:axon guidance; IMP:MGI.
 GO:0009880; P:embryonic pattern specification; IMP:MGI.
 GO:0001755; P:neural crest cell migration; IMP:MGI.
 GO:0042102; P:positive regulation of T cell proliferation; IDA:MGI. 

Interpro

 IPR008972; Cupredoxin.
 IPR001799; Ephrin.
 IPR019765; Ephrin_CS. 

Pfam

 PF00812; Ephrin 

SMART

  

PROSITE

 PS01299; EPHRIN_RBD_1
 PS51551; EPHRIN_RBD_2 

PRINTS

 PR01347; EPHRIN.