UniProt Accession

 CHST3_HUMAN; Q7LGC8; O75099; Q52M30 

Genbank Protein ID

 AB012192; AB017915; BC093690; BC104856 

Genbank Nucleotide ID

 BAA32576.1; BAA36348.1; AAH93690.1; AAI04857.1 

Protein Name

 Carbohydrate sulfotransferase 3 

Protein Synonyms/Alias

 Chondroitin 6-O-sulfotransferase 1; C6ST-1; Chondroitin 6-sulfotransferase; Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 0; GST-0 

Gene Name

 CHST3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
273	RKEHMALKAVRIRQL	methylation	[1]
419	SGIYSTQKNSSEQFE	ubiquitination	[2]

Reference

 [1] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues of keratan sulfate, another glycosaminoglycan, and the Gal residues in sialyl N- acetyllactosamine (sialyl LacNAc) oligosaccharides. May play a role in the maintenance of naive T-lymphocytes in the spleen. 

Sequence Annotation

 NP_BIND 141 147 PAPS (By similarity).
 NP_BIND 301 309 PAPS (By similarity).
 CARBOHYD 63 63 N-linked (GlcNAc...) (Potential).
 CARBOHYD 74 74 N-linked (GlcNAc...) (Potential).
 CARBOHYD 96 96 N-linked (GlcNAc...) (Potential).
 CARBOHYD 256 256 N-linked (GlcNAc...) (Potential).
 CARBOHYD 420 420 N-linked (GlcNAc...) (Potential).
 CARBOHYD 464 464 N-linked (GlcNAc...) (Potential).  

Keyword

 Carbohydrate metabolism; Complete proteome; Disease mutation; Glycoprotein; Golgi apparatus; Membrane; Polymorphism; Reference proteome; Signal-anchor; Transferase; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 479 AA 

Protein Sequence

Gene Ontology

 GO:0000139; C:Golgi membrane; TAS:Reactome.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0008459; F:chondroitin 6-sulfotransferase activity; IDA:UniProtKB.
 GO:0050698; F:proteoglycan sulfotransferase activity; IEA:Compara.
 GO:0005975; P:carbohydrate metabolic process; TAS:Reactome.
 GO:0030206; P:chondroitin sulfate biosynthetic process; IDA:UniProtKB.
 GO:0043029; P:T cell homeostasis; IEA:Compara. 

Interpro

 IPR016469; Carbohydrate_sulfotransferase.
 IPR027417; P-loop_NTPase.
 IPR000863; Sulfotransferase_dom. 

Pfam

 PF00685; Sulfotransfer_1 

SMART

  

PROSITE

  

PRINTS