UniProt Accession

 GSTO2_HUMAN; Q9H4Y5; A8K771; B4DJW6; E7ESD6; Q49TW5; Q5GM70; Q5JU15; Q86WP3 

Genbank Protein ID

 AY350731; AY209189; AK291886; AK296266; AL139341; AL162742; AL162742; CH471066; BC046194; BC056918; AY191318 

Genbank Nucleotide ID

 AAR02452.1; AAP47743.1; BAF84575.1; BAG58978.1; CAC16040.1; CAI12107.1; EAW49600.1; AAH56918.1; AAO23573.1 

Protein Name

 Glutathione S-transferase omega-2 

Protein Synonyms/Alias

 GSTO-2; Glutathione S-transferase omega 2-2; GSTO 2-2; Glutathione-dependent dehydroascorbate reductase; Monomethylarsonic acid reductase; MMA(V) reductase 

Gene Name

 GSTO2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
11	DATRTLGKGSQPPGP	ubiquitination	[1]
59	VNINLRNKPEWYYTK	ubiquitination	[1]
101	DDAYPGRKLFPYDPY	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA). 

Sequence Annotation

 DOMAIN 22 101 GST N-terminal.
 DOMAIN 106 231 GST C-terminal.
 REGION 85 86 Glutathione binding.
 ACT_SITE 32 32 Nucleophile.
 BINDING 59 59 Glutathione.
 BINDING 72 72 Glutathione; via amide nitrogen and  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Oxidoreductase; Polymorphism; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 243 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0045174; F:glutathione dehydrogenase (ascorbate) activity; IDA:UniProtKB.
 GO:0004364; F:glutathione transferase activity; IEA:EC.
 GO:0050610; F:methylarsonate reductase activity; IEA:EC.
 GO:0071243; P:cellular response to arsenic-containing substance; IDA:UniProtKB.
 GO:0019852; P:L-ascorbic acid metabolic process; IDA:UniProtKB.
 GO:0006805; P:xenobiotic metabolic process; IDA:UniProtKB. 

Interpro

 IPR010987; Glutathione-S-Trfase_C-like.
 IPR004045; Glutathione_S-Trfase_N.
 IPR017933; Glutathione_S_Trfase/Cl_chnl_C.
 IPR005442; GST_omega.
 IPR012336; Thioredoxin-like_fold. 

Pfam

  

SMART

  

PROSITE

 PS50405; GST_CTER
 PS50404; GST_NTER 

PRINTS

 PR01625; GSTRNSFRASEO.