CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032001
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tubulin-specific chaperone E 
Protein Synonyms/Alias
 cDNA FLJ59210, highly similar to Tubulin-specific chaperone E 
Gene Name
 TBCE 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
60HEGTVYFKCRHPTGGubiquitination[1]
86TDFLTAIKNRYVLEDubiquitination[1]
128KQQSQLSKLQEVSLRubiquitination[1]
192NVSENKLKFPSGSVLubiquitination[2, 3]
397CLRNPLTKEDKEAETubiquitination[1]
417IASIGQLKTLNKCEIubiquitination[1]
421GQLKTLNKCEILPEEubiquitination[1]
438RAELDYRKAFGNEWKubiquitination[1]
493TQQPLMLKNQLLTLKubiquitination[1]
502QLLTLKIKYPHQLDQacetylation[4, 5]
514LDQKVLEKQLPGSMTacetylation[4, 5, 6]
514LDQKVLEKQLPGSMTubiquitination[2, 3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [6] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 578 AA 
Protein Sequence
MSDTLTADVI GRRVEVNGEH ATVRFAGVVP PVAGPWLGVE WDNPERGKHD GSHEGTVYFK 60
CRHPTGGSFI RPNKVNFGTD FLTAIKNRYV LEDGPEEDRK EQIVTIGNKP VETIGFDSIM 120
KQQSQLSKLQ EVSLRNCAVS CAGEKGGVAE ACPNIRKVDL SKNLLSSWDE VIHIADQLRH 180
LEVLNVSENK LKFPSGSVLT GTLSVLKVLV LNQTGITWAE AHAQCGGSRH GLDMQKDASK 240
FVDLCVLQKC STSNCIISAK DHTSMRMNVA KVLRCVAGCP GLEELYLESN NIFISERPTD 300
VLQTVKLLDL SSNQLIDENQ LYLIAHLPRL EQLILSDTGI SSLHFPDAGI GCKTSMFPSL 360
KYLVVNDNQI SQWSFFNELE KLPSLRALSC LRNPLTKEDK EAETARLLII ASIGQLKTLN 420
KCEILPEERR RAELDYRKAF GNEWKQAGGH KDPEKNRLSE EFLTAHPRYQ FLCLKYGAPE 480
DWELKTQQPL MLKNQLLTLK IKYPHQLDQK VLEKQLPGSM TIQKVKGLLS RLLKVPVSDL 540
LLSYESPKKP GREIELENDL KSLQFYSVEN GDCLLVRW 578 
Gene Ontology
 GO:0005840; C:ribosome; IEA:InterPro.
 GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
 GO:0006412; P:translation; IEA:InterPro. 
Interpro
 IPR000938; CAP-Gly_domain.
 IPR001931; Ribosomal_S21e. 
Pfam
 PF01302; CAP_GLY
 PF01249; Ribosomal_S21e 
SMART
 SM01052; CAP_GLY 
PROSITE
 PS00845; CAP_GLY_1
 PS50245; CAP_GLY_2 
PRINTS