UniProt Accession

 GPP1_YEAST; P41277; D6VVM8; P38012 

Genbank Protein ID

 D50471; Z38060; BK006942 

Genbank Nucleotide ID

 BAA09060.1; CAA86169.1; DAA08494.1 

Protein Name

 (DL)-glycerol-3-phosphatase 1 

Protein Synonyms/Alias

 Related to HOR2 protein 2 

Gene Name

 RHR2 

Gene Synonyms/Alias

 GPP1; YIL053W 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
64	RTYDAIAKFAPDFAD	acetylation	[1]
64	RTYDAIAKFAPDFAD	ubiquitination	[2]
77	ADEEYVNKLEGEIPE	acetylation	[1]
85	LEGEIPEKYGEHSIE	acetylation	[1]
124	GTRDMAKKWFDILKI	acetylation	[1]
130	KKWFDILKIKRPEYF	acetylation	[1]
130	KKWFDILKIKRPEYF	ubiquitination	[3]
144	FITANDVKQGKPHPE	acetylation	[1]
144	FITANDVKQGKPHPE	ubiquitination	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047]
 [3] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Major isoform of DL-glycerol-3-phosphatase involved in glycerol biosynthesis. Plays a role in osmoadaptation and required for adaptation to anaerobic conditions. 

Sequence Annotation

 MOD_RES 90 90 Phosphoserine.
 CROSSLNK 64 64 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; Hydrolase; Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 250 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0000121; F:glycerol-1-phosphatase activity; IDA:SGD.
 GO:0006114; P:glycerol biosynthetic process; IMP:SGD.
 GO:0006970; P:response to osmotic stress; TAS:SGD. 

Interpro

 IPR023214; HAD-like_dom.
 IPR006402; HAD-SF_hydro_IA_v3.
 IPR023198; PGP_dom2. 

Pfam

 PF00702; Hydrolase 

SMART

  

PROSITE

  

PRINTS