CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019983
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Thymidine phosphorylase 
Protein Synonyms/Alias
 TP; TdRPase 
Gene Name
 Tymp 
Gene Synonyms/Alias
 Ecgf1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
101WHQQLVDKHSTGGVGubiquitination[1]
207ITASILSKKAVEGLSubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity). 
Sequence Annotation
 BINDING 102 102 Substrate (By similarity).
 BINDING 188 188 Substrate (By similarity).
 BINDING 203 203 Substrate (By similarity).
 BINDING 207 207 Substrate (By similarity).  
Keyword
 Complete proteome; Glycosyltransferase; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 471 AA 
Protein Sequence
MAAPGTPPPS ASGGGGGEPR QLPELIRLKR DGGHLREADI RNFVHAVIDG RAQDTQIGAM 60
LMAIRLQGMN LEETSVLTRA LAESGQQLEW PKAWHQQLVD KHSTGGVGDK VSLVLAPALA 120
ACGCKVPMIS GRSLGHTGGT LDKLESIPGF GVTQSPEQML HILEEVGCCI VGQSAKLVPA 180
DGILYAARDV TATVDSVPLI TASILSKKAV EGLSTLVVDV KFGGAAVFPD QEKARELAKM 240
LVRVGVSLGL KVAAALTAMD NPLGRSVGHT LEVEEALLCL DGAGPPDLRD LVIRLGGAIL 300
WISGQAETQD QGAARVAAAL DDGSARRRFQ LMLSAQGVDP GLAKALCSGS PTQRRQLLPH 360
AREQEELLAP ADGIVECVRA LPLARVLHDL GAGRSRAGQP IRPGVGAEVL VDVGQCLSRG 420
TPWLRVHLDG PALSSQQRRT LQGALVLSDR APFKVPSPFA ELVLPPTIAQ P 471 
Gene Ontology
 GO:0004645; F:phosphorylase activity; TAS:MGI.
 GO:0016154; F:pyrimidine-nucleoside phosphorylase activity; IEA:InterPro.
 GO:0009032; F:thymidine phosphorylase activity; IEA:EC.
 GO:0006935; P:chemotaxis; TAS:MGI.
 GO:0009887; P:organ morphogenesis; TAS:MGI.
 GO:0006206; P:pyrimidine nucleobase metabolic process; IEA:InterPro.
 GO:0006213; P:pyrimidine nucleoside metabolic process; IEA:InterPro. 
Interpro
 IPR000312; Glycosyl_Trfase_fam3.
 IPR017459; Glycosyl_Trfase_fam3_N_dom.
 IPR013102; PYNP_C.
 IPR018090; Pyrmidine_PPas_bac/euk.
 IPR000053; Pyrmidine_PPase. 
Pfam
 PF02885; Glycos_trans_3N
 PF00591; Glycos_transf_3
 PF07831; PYNP_C 
SMART
 SM00941; PYNP_C 
PROSITE
  
PRINTS