| Tag | Content |
|---|
| CPLM ID | CPLM-007064 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Vacuolar protein sorting-associated protein 41 |
Protein Synonyms/Alias | Vacuolar morphogenesis protein 2 |
Gene Name | VPS41 |
Gene Synonyms/Alias | FET2; VAM2; YDR080W; D446; YD8554.13 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 665 | SEPTASSKEEGSNIT | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Required for vacuolar assembly and vacuolar traffic. Acts as component of the HOPS complex that acts during the docking stage of vacuole fusion. HOPS is an effector for the vacuolar Rab GTPase YPT7 and is required for vacuolar SNARE complex assembly. It remains bound to SNARE complexes after vacuole fusion. |
Sequence Annotation | REPEAT 114 152 WD 1.
REPEAT 153 192 WD 2.
REPEAT 194 234 WD 3.
REPEAT 240 280 WD 4.
REPEAT 324 366 WD 5.
REPEAT 753 901 CHCR.
MOD_RES 26 26 Phosphoserine.
MOD_RES 53 53 Phosphoserine. |
Keyword | Complete proteome; Phosphoprotein; Protein transport; Reference proteome; Repeat; Transport; Vacuole; WD repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 992 AA |
Protein Sequence | MTTDNHQNDS VLDQQSGERT IDESNSISDE NNVDNKREDV NVTSPTKSVS CISQAENGVA 60
SRTDESTITG SATDAETGDD DDDDDDDDDE DEDDEDEPPL LKYTRISQLP KNFFQRDSIS 120
SCLFGDTFFA FGTHSGILHL TTCAFEPIKT IKCHRSSILC INTDGKYFAT GSIDGTVIIG 180
SMDDPQNITQ YDFKRPINSV ALHSNFQASR MFVSGGMAGD VVLSQRNWLG NRIDIVLNKK 240
KKKKTRKDDL SSDMKGPIMG IYTMGDLILW MDDDGITFCD VPTRSQLLNI PFPSRIFNVQ 300
DVRPDLFRPH VHFLESDRVV IGWGSNIWLF KVSFTKDSNS IKSGDSNSQS NNMSHFNPTT 360
NIGSLLSSAA SSFRGTPDKK VELECHFTVS MLITGLASFK DDQLLCLGFD IDIEEEATID 420
EDMKEGKNFS KRPENLLAKG NAPELKIVDL FNGDEIYNDE VIMKNYEKLS INDYHLGKHI 480
DKTTPEYYLI SSNDAIRVQE LSLKDHFDWF MERKQYYKAW KIGKYVIGSE ERFSIGLKFL 540
NSLVTKKDWG TLVDHLNIIF EETLNSLDSN SYDVTQNVLK EWADIIEILI TSGNIVEIAP 600
LIPKKPALRK SVYDDVLHYF LANDMINKFH EYITKWDLKL FSVEDFEEEL ETRIEAASEP 660
TASSKEEGSN ITYRTELVHL YLKENKYTKA IPHLLKAKDL RALTIIKIQN LLPQYLDQIV 720
DIILLPYKGE ISHISKLSIF EIQTIFNKPI DLLFENRHTI SVARIYEIFE HDCPKSFKKI 780
LFCYLIKFLD TDDSFMISPY ENQLIELYSE YDRQSLLPFL QKHNNYNVES AIEVCSSKLG 840
LYNELIYLWG KIGETKKALS LIIDELKNPQ LAIDFVKNWG DSELWEFMIN YSLDKPNFTK 900
AILTCSDETS EIYLKVIRGM SDDLQIDNLQ DIIKHIVQEN SLSLEVRDNI LVIINDETKK 960
FANEFLKIRS QGKLFQVDES DIEINDDLNG VL 992 |
Gene Ontology | GO:0005768; C:endosome; IDA:SGD. GO:0000329; C:fungal-type vacuole membrane; IDA:SGD. GO:0030897; C:HOPS complex; IPI:SGD. GO:0017112; F:Rab guanyl-nucleotide exchange factor activity; IPI:SGD. GO:0006886; P:intracellular protein transport; IEA:InterPro. GO:0034727; P:piecemeal microautophagy of nucleus; IMP:SGD. GO:0015031; P:protein transport; IMP:SGD. GO:0035542; P:regulation of SNARE complex assembly; IDA:SGD. GO:0032889; P:regulation of vacuole fusion, non-autophagic; IDA:SGD. GO:0006624; P:vacuolar protein processing; IMP:SGD. GO:0042144; P:vacuole fusion, non-autophagic; IDA:SGD. GO:0016192; P:vesicle-mediated transport; IMP:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |