CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023880
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 SH3 and multiple ankyrin repeat domains protein 1 
Protein Synonyms/Alias
 Shank1; Somatostatin receptor-interacting protein; SSTR-interacting protein; SSTRIP 
Gene Name
 SHANK1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
169KQTNLDEKQLAKLHTacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. 
Sequence Annotation
 REPEAT 212 245 ANK 1.
 REPEAT 246 278 ANK 2.
 REPEAT 279 312 ANK 3.
 REPEAT 313 345 ANK 4.
 REPEAT 346 378 ANK 5.
 REPEAT 379 395 ANK 6.
 DOMAIN 554 613 SH3.
 DOMAIN 663 757 PDZ.
 DOMAIN 2098 2161 SAM.  
Keyword
 Alternative splicing; ANK repeat; Cell junction; Cell membrane; Complete proteome; Cytoplasm; Differentiation; Membrane; Neurogenesis; Polymorphism; Postsynaptic cell membrane; Reference proteome; Repeat; SH3 domain; Synapse. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2161 AA 
Protein Sequence
MTHSPATSED EERHSASECP EGGSESDSSP DGPGRGPRGT RGQGSGAPGS LASVRGLQGR 60
SMSVPDDAHF SMMVFRIGIP DLHQTKCLRF NPDATIWTAK QQVLCALSES LQDVLNYGLF 120
QPATSGRDAN FLEEERLLRE YPQSFEKGVP YLEFRYKTRV YKQTNLDEKQ LAKLHTKTGL 180
KKFLEYVQLG TSDKVARLLD KGLDPNYHDS DSGETPLTLA AQTEGSVEVI RTLCLGGAHI 240
DFRARDGMTA LHKAACARHC LALTALLDLG GSPNYKDRRG LTPLFHTAMV GGDPRCCELL 300
LFNRAQLGIA DENGWQEIHQ ACQRGHSQHL EHLLFYGAEP GAQNASGNTA LHICALYNKE 360
TCARILLYRG ADKDVKNNNG QTPFQVAVIA GNFELGELIR NHREQDVVPF QESPKYAARR 420
RGPPGTGLTV PPALLRANSD TSMALPDWMV FSAPGAASSG APGPTSGSQG QSQPSAPTTK 480
LSSGTLRSAS SPRGARARSP SRGRHPEDAK RQPRGRPSSS GTPREGPAGG TGGSGGPGGS 540
LGSRGRRRKL YSAVPGRSFM AVKSYQAQAE GEISLSKGEK IKVLSIGEGG FWEGQVKGRV 600
GWFPSDCLEE VANRSQESKQ ESRSDKAKRL FRHYTVGSYD SFDAPSLMDG IGPGSDYIIK 660
EKTVLLQKKD SEGFGFVLRG AKAQTPIEEF TPTPAFPALQ YLESVDEGGV AWRAGLRMGD 720
FLIEVNGQNV VKVGHRQVVN MIRQGGNTLM VKVVMVTRHP DMDEAVHKKA PQQAKRLPPP 780
TISLRSKSMT SELEEMEYEQ QPAPVPSMEK KRTVYQMALN KLDEILAAAQ QTISASESPG 840
PGGLASLGKH RPKGFFATES SFDPHHRAQP SYERPSFLPP GPGLMLRQKS IGAAEDDRPY 900
LAPPAMKFSR SLSVPGSEDI PPPPTTSPPE PPYSTPPVPS SSGRLTPSPR GGPFNPGSGG 960
PLPASSPASF DGPSPPDTRV GSREKSLYHS GPLPPAHHHP PHHHHHHAPP PQPHHHHAHP 1020
PHPPEMETGG SPDDPPPRLA LGPQPSLRGW RGGGPSPTPG APSPSHHGSA GGGGGSSQGP 1080
ALRYFQLPPR AASAAMYVPA RSGRGRKGPL VKQTKVEGEP QKGGGLPPAP SPTSPASPQP 1140
PPAVAAPSEK NSIPIPTIII KAPSTSSSGR SSQGSSTEAE PPTQPEPTGG GGGGGSSPSP 1200
APAMSPVPPS PSPVPTPASP SGPATLDFTS QFGAALVGAA RREGGWQNEA RRRSTLFLST 1260
DAGDEDGGDG GLGTGAAPGP RLRHSKSIDE GMFSAEPYLR LESAGSGAGY GGYGAGSRAY 1320
GGGGGSSAFT SFLPPRPLVH PLTGKALDPA SPLGLALAAR ERALKESSEG GGAPQPPPRP 1380
PSPRYEAPPP TPHHHSPHAH HEPVLRLWGA SPPDPARREL GYRAGLGSQE KSLPASPPAA 1440
RRSLLHRLPP TAPGVGPLLL QLGTEPPAPH PGVSKPWRSA APEEPERLPL HVRFLENCQP 1500
RAPVTSGRGP PSEDGPGVPP PSPRRSVPPS PTSPRASEEN GLPLLVLPPP APSVDVEDGE 1560
FLFVEPLPPP LEFSNSFEKP ESPLTPGPPH PLPDTPAPAT PLPPVPPPAV AAAPPTLDST 1620
ASSLTSYDSE VATLTQGASA APGDPHPPGP PAPAAPAPAA PQPGPDPPPG TDSGIEEVDS 1680
RSSSDHPLET ISSASTLSSL SAEGGGSAGG GGGAGAGVAS GPELLDTYVA YLDGQAFGGS 1740
STPGPPYPPQ LMTPSKLRGR ALGASGGLRP GPSGGLRDPV TPTSPTVSVT GAGTDGLLAL 1800
RACSGPPTAG VAGGPVAVEP EVPPVPLPTA SSLPRKLLPW EEGPGPPPPP LPGPLAQPQA 1860
SALATVKASI ISELSSKLQQ FGGSSAAGGA LPWARGGSGG GGDSHHGGAS YVPERTSSLQ 1920
RQRLSDDSQS SLLSKPVSSL FQNWPKPPLP PLPTGTGVSP TAAAAPGATS PSASSSSTST 1980
RHLQGVEFEM RPPLLRRAPS PSLLPASEHK VSPAPRPSSL PILPSGPLYP GLFDIRGSPT 2040
GGAGGSADPF APVFVPPHPG ISGGLGGALS GASRSLSPTR LLSLPPDKPF GAKPLGFWTK 2100
FDVADWLEWL GLAEHRAQFL DHEIDGSHLP ALTKEDYVDL GVTRVGHRMN IDRALKFFLE 2160
R 2161 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0060076; C:excitatory synapse; ISS:BHF-UCL.
 GO:0017146; C:N-methyl-D-aspartate selective glutamate receptor complex; IEA:Compara.
 GO:0005886; C:plasma membrane; ISS:BHF-UCL.
 GO:0014069; C:postsynaptic density; ISS:BHF-UCL.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
 GO:0071532; F:ankyrin repeat binding; ISS:BHF-UCL.
 GO:0030160; F:GKAP/Homer scaffold activity; ISS:BHF-UCL.
 GO:0042802; F:identical protein binding; ISS:BHF-UCL.
 GO:0035255; F:ionotropic glutamate receptor binding; ISS:BHF-UCL.
 GO:0097110; F:scaffold protein binding; ISS:BHF-UCL.
 GO:0017124; F:SH3 domain binding; ISS:BHF-UCL.
 GO:0008306; P:associative learning; ISS:BHF-UCL.
 GO:0007016; P:cytoskeletal anchoring at plasma membrane; NAS:UniProtKB.
 GO:0060997; P:dendritic spine morphogenesis; ISS:BHF-UCL.
 GO:0050894; P:determination of affect; IMP:BHF-UCL.
 GO:0046959; P:habituation; IEA:Compara.
 GO:0007616; P:long-term memory; ISS:BHF-UCL.
 GO:0032232; P:negative regulation of actin filament bundle assembly; IEA:Compara.
 GO:0050885; P:neuromuscular process controlling balance; ISS:BHF-UCL.
 GO:0042048; P:olfactory behavior; IEA:Compara.
 GO:0060999; P:positive regulation of dendritic spine development; IEA:Compara.
 GO:2000463; P:positive regulation of excitatory postsynaptic membrane potential; ISS:BHF-UCL.
 GO:0006461; P:protein complex assembly; ISS:BHF-UCL.
 GO:0035418; P:protein localization to synapse; ISS:BHF-UCL.
 GO:2000311; P:regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; ISS:BHF-UCL.
 GO:0060013; P:righting reflex; IEA:Compara.
 GO:0035176; P:social behavior; IMP:BHF-UCL.
 GO:0060074; P:synapse maturation; IEA:Compara.
 GO:0071625; P:vocalization behavior; IMP:BHF-UCL. 
Interpro
 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom.
 IPR001478; PDZ.
 IPR001660; SAM.
 IPR013761; SAM/pointed.
 IPR021129; SAM_type1.
 IPR011511; SH3_2.
 IPR001452; SH3_domain. 
Pfam
 PF12796; Ank_2
 PF00595; PDZ
 PF00536; SAM_1
 PF07653; SH3_2 
SMART
 SM00248; ANK
 SM00228; PDZ
 SM00454; SAM
 SM00326; SH3 
PROSITE
 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT
 PS50106; PDZ
 PS50105; SAM_DOMAIN
 PS50002; SH3 
PRINTS