| Tag | Content |
|---|
| CPLM ID | CPLM-003974 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Growth arrest-specific protein 2 |
Protein Synonyms/Alias | GAS-2 |
Gene Name | Gas2 |
Gene Synonyms/Alias | Gas-2 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 100 | PLKKIPCKASAPSGS | ubiquitination | [1] | | 141 | SEGLVLHKQPREVCL | ubiquitination | [1] | | 208 | NLLDDAVKRISEDPP | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May play a role in chondrocyte proliferation and differentiation, and in limb myogenesis. May be involved in the regulation of the apoptosis in the interdigital tissues of the developing hindlimb. May be involved in the membrane ruffling process. |
Sequence Annotation | DOMAIN 35 157 CH.
DOMAIN 198 271 GAR.
MOD_RES 283 283 Phosphoserine. |
Keyword | 3D-structure; Apoptosis; Cell cycle; Cell shape; Complete proteome; Cytoplasm; Cytoskeleton; Growth arrest; Membrane; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 314 AA |
Protein Sequence | MMCTALSPKV RSGPGLSDMH QYSQWLASRH EANLLPMKED LALWLTNLLG KEITAETFME 60
KLDNGALLCQ LAATVQEKFK ESMDANKPAK TLPLKKIPCK ASAPSGSFFA RDNTANFLSW 120
CRDLGVDETC LFESEGLVLH KQPREVCLCL LELGRIAARY GVEPPGLIKL EKEIEQEETL 180
SAPSPSPSPS SKSSGKKSTG NLLDDAVKRI SEDPPCKCPT KFCVERLSQG RYRVGEKILF 240
IRMLHNKHVM VRVGGGWETF AGYLLKHDPC RMLQISRVDG KTSPVQSKSP TLKDMNPDNY 300
LVVSATYKAK KEIK 314 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-KW. GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell. GO:0016020; C:membrane; IEA:UniProtKB-SubCell. GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. GO:0007050; P:cell cycle arrest; IEA:UniProtKB-KW. GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW. |
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Pfam | |
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PRINTS | |