CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017621
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger and BTB domain-containing protein 34 
Protein Synonyms/Alias
  
Gene Name
 ZBTB34 
Gene Synonyms/Alias
 KIAA1993 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
30NELRLQGKLCDIIVHubiquitination[1]
152PESRNGVKDSSFFANubiquitination[1]
188RMETTPSKALRSRLQubiquitination[1, 2]
412CGKKYTRKDQLEYHIubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
 May be a transcriptional repressor. 
Sequence Annotation
 DOMAIN 32 96 BTB.
 ZN_FING 372 394 C2H2-type 1.
 ZN_FING 400 422 C2H2-type 2.
 ZN_FING 428 451 C2H2-type 3.  
Keyword
 Complete proteome; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 500 AA 
Protein Sequence
MDSSSFIQFD VPEYSSTVLS QLNELRLQGK LCDIIVHIQG QPFRAHKAVL AASSPYFRDH 60
SALSTMSGLS ISVIKNPNVF EQLLSFCYTG RMSLQLKDVV SFLTAASFLQ MQCVIDKCTQ 120
ILESIHSKIS VGDVDSVTVG AEENPESRNG VKDSSFFANP VEISPPYCSQ GRQPTASSDL 180
RMETTPSKAL RSRLQEEGHS DRGSSGSVSE YEIQIEGDHE QGDLLVRESQ ITEVKVKMEK 240
SDRPSCSDSS SLGDDGYHTE MVDGEQVVAV NVGSYGSVLQ HAYSYSQAAS QPTNVSEAFG 300
SLSNSSPSRS MLSCFRGGRA RQKRALSVHL HSDLQGLVQG SDSEAMMNNP GYESSPRERS 360
ARGHWYPYNE RLICIYCGKS FNQKGSLDRH MRLHMGITPF VCKFCGKKYT RKDQLEYHIR 420
GHTDDKPFRC EICGKCFPFQ GTLNQHLRKN HPGVAEVRSR IESPERTDVY VEQKLENDAS 480
ASEMGLDSRM EIHTVSDAPD 500 
Gene Ontology
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR000210; BTB/POZ-like.
 IPR011333; BTB/POZ_fold.
 IPR013069; BTB_POZ.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF00651; BTB 
SMART
 SM00225; BTB
 SM00355; ZnF_C2H2 
PROSITE
 PS50097; BTB
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS