CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038470
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Histone-lysine N-methyltransferase EHMT1 
Protein Synonyms/Alias
  
Gene Name
 Ehmt1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
777DAVKYLIKAGAQVDPubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 ANK repeat; Chromosome; Complete proteome; Methyltransferase; Nucleus; Reference proteome; Repeat; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1248 AA 
Protein Sequence
MVAGMAEQAV LAKQETKQDC CMKTELLRED TPMAADEGST EKQEGETPMA ADGETNGSCE 60
KSGDPSHLNA PKHTQENTRA SPQEGTNRVS RVAENGVSER DTEVGKQNHV TADDFMQTSV 120
IGSNGYFLNK PALQGQPLRT PNILTSSLPG HAAKTLPGGA SKCRTLSALP QTPTTAPTVP 180
GEGSADTEDR KPTASGTDVR VHRARKTMPK SILGLHAASK DHREVQDHKE PKEDINRNIS 240
ECGRQQLLPT FPALHQSLPQ NQCYMATTKS QTACLPFVLA AAVSRKKKRR MGTYSLVPKK 300
KTKVLKQRTV IEMFKSITHS TVGAKGEKAL DDSALHVNGE SLEMDSEDED SDELEDDEDH 360
GAEQAAAFPT EDSRTSKESM SETDRAAKMD GDSEEEQESP DTGEDEDGGD ESDLSSESSI 420
KKKFLKRRGK TDSPWIKPAR KRRRRSRKKP SSMLGSEACK SSPGSMEQAA LGDSAGYMEV 480
SLDSLDLRVR GILSSQTENE GLASGPDVLG TDGLQEVPLC SCRMETPKSR EISTLANNQC 540
MATESVDHEG NFMECQPESS ISHRFHKDCA SRVNNASYCP HCGEEASKAK EVTIAKADTT 600
STVTLAPGQE KSLAAEGRAD TTTGSIAGAP EDERSQSTAP QAPECFDPAG PAGLVRPTSG 660
LSQGPGKETL ESALIALDSE KPKKLRFHPK QLYFSARQGE LQKVLLMLVD GIDPNFKMEH 720
QSKRSPLHAA AEAGHVDICH MLVQAGANID TCSEDQRTPL MEAAENNHLD AVKYLIKAGA 780
QVDPKDAEGS TCLHLAAKKG HYDVVQYLLS NGQMDVNCQD DGGWTPMIWA TEYKHVELVK 840
LLLSKGSDIN IRDNEENICL HWAAFSGCVD IAEILLAAKC DLHAVNIHGD SPLHIAAREN 900
RYDCVVLFLS RDSDVTLKNK EGETPLQCAS LSSQVWSALQ MSKALRDSAP DKPVAVEKTV 960
SRDIARGYER IPIPCVNAVD SELCPTNYKY VSQNCVTSPM NIDRNITHLQ YCVCVDDCSS 1020
STCMCGQLSM RCWYDKDGRL LPEFNMAEPP LIFECNHACS CWRNCRNRVV QNGLRARLQL 1080
YRTQDMGWGV RSLQDIPLGT FVCEYVGELI SDSEADVREE DSYLFDLDNK DGEVYCIDAR 1140
FYGNVSRFIN HHCEPNLVPV RVFMSHQDLR FPRIAFFSTR LIQAGEQLGF DYGERFWDVK 1200
GKLFSCRCGS SKCRHSSAAL AQRQASAAQE PQENGLPDTS SAAAADPL 1248 
Gene Ontology
 GO:0005694; C:chromosome; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:MGI. 
Interpro
 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom.
 IPR007728; Pre-SET_dom.
 IPR003606; Pre-SET_Zn-bd_sub.
 IPR001214; SET_dom. 
Pfam
 PF00023; Ank
 PF12796; Ank_2
 PF05033; Pre-SET
 PF00856; SET 
SMART
 SM00248; ANK
 SM00468; PreSET
 SM00317; SET 
PROSITE
 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT
 PS50867; PRE_SET
 PS50280; SET 
PRINTS
 PR01415; ANKYRIN.