| Tag | Content |
|---|
| CPLM ID | CPLM-014953 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Keratin, type II cytoskeletal 75 |
Protein Synonyms/Alias | Cytokeratin-75; CK-75; Keratin-6 hair follicle; Keratin-75; K75; Type II keratin-K6hf; Type-II keratin Kb18 |
Gene Name | Krt75 |
Gene Synonyms/Alias | Kb18 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 249 | NEFVGLKKDVDGAYM | acetylation | [1] | | 258 | VDGAYMNKVELEAKV | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle (By similarity). |
Sequence Annotation | REGION 1 139 Head.
REGION 140 449 Rod.
REGION 140 175 Coil 1A.
REGION 176 194 Linker 1.
REGION 195 287 Coil 1B.
REGION 288 310 Linker 12.
REGION 311 449 Coil 2.
REGION 450 542 Tail.
MOD_RES 72 72 Phosphoserine (By similarity).
MOD_RES 304 304 Phosphoserine (By similarity). |
Keyword | Coiled coil; Complete proteome; Intermediate filament; Keratin; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 542 AA |
Protein Sequence | MSRQSTVTFH SGSRRGFSTA SATTPTAGRS RFSSVSVARS SGNSGGLGRI SGIGSGFGSR 60
SLYNLGATRP VSVGGCAGSG FRSGFGGRAS SSFGYGGGFG GPGFPVCPSG SIQEVTVNQS 120
LLTPLNLQID PTIQRVRKEE REQIKTLNNK FASFIDKVRF LEQQNKVLET KWNLLQEQGS 180
RTVRQNLEPF FDAYVNDLRR QLDSVTAERG RLDAELRHMQ EVVEDFKVRY EDEINKRAAA 240
ENEFVGLKKD VDGAYMNKVE LEAKVDSLTD QINFYRMVYE AELSQMQNQV SDTSVVLSMD 300
NNRSLDLDSI IAEVKAQYED IANRSRAEAE SWYQTKYEEL QVTAGRHGDD LRNTKQEISE 360
MNRMIQRLRS EIDAVKKQCS SLQTAISDTE QRGELALKDA RAKLVELEDA LQKAKQDMAR 420
LLREYQELMN VKLALDVEIA TYRKLLEGEE CRLSGEGVSP VNISVVTSTV SSGYGGGTNI 480
GGGSLGLGGN SGYSFTTTGG HSLGTGLGGS GFTTSSSRGP VGSGSSIKFV SSTSSSRKSY 540
KH 542 |
Gene Ontology | GO:0045095; C:keratin filament; IEA:InterPro. GO:0005198; F:structural molecule activity; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |