CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038699
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Mediator of RNA polymerase II transcription subunit 13-like 
Protein Synonyms/Alias
  
Gene Name
 Med13l 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
749SEDGFGTKDVTTPGHacetylation[1, 2]
764STPVPDGKNAMSIFSacetylation[3]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2207 AA 
Protein Sequence
MTAAANWVAN GASLEDCHSN LFSLAELTGI KWRRYNFGGH GDCGPIISAP AQDDPILLSF 60
IRCLQANLLC VWRRDVKPDC KELWIFWWGD EPNLVGVIHH ELQVVEEGLW ENGLSYECRT 120
LLFKAIHNLL ERCLMDKNFV RIGKWFVRPY DKDEKPVNKS EHLSCAFTFF LHGESNVCTS 180
VEIAQHQPIY LINEEHLHMA QSSPAPFQVL VSPYGLNGTL TGHAYKMSDP AARKLIEEWH 240
CFYPMVLRKR EEPREEAELG YDDDFPVAVE VIVGGVRMVY PSAFVLVSQN DIPVPQSGHG 300
TVAQQGLGSV KDPSNCGMPL TPPTSPEQVV IGESGGVQSA ASHLGSQDGG MSTMHSPKRS 360
RKTPPKLHSH MVRRVWRECI LSRAQSKRSQ MSTPTREEEA AHSPAAWDFV DPTQRVSCSC 420
SRHKLLKRCA VGPSRPPAIS QPGFSAGLPS SSSLPPPASS KHKTTERQEK GDKLQKRPLV 480
PFHHRPSVAE ELCVEQDAPG QKLGLAGIDA SLEVSNTRKY DKQMAVPSRN TSKQMNLNPM 540
DSPHSPISPL PPTLSPQPRG QEAESLDPPS VPVNPALYGN GLDLQQLSTI EDRTVLVGQR 600
LPLMAEASET ALYSGLRPSY TESSDRWWQS FRLPSSEDAE FRPPELQGER FDTALDLNPE 660
STALQRLLAQ PNKRFKIWQD EQPQVQPLPF LDPSPLSQQP GDTLGEVNDP YTFEDGDIKY 720
IFTANKKCKQ GTEKDSLKKN KSEDGFGTKD VTTPGHSTPV PDGKNAMSIF SSATKTDVRQ 780
DSAAGRAGSG SLTQVTDLAP SLHDLDNIFD NSDEDELGAV SPALRSSKMP TVGTEERPPG 840
KDGRAAGPYP PTVADLQRMF PTPPSLEQHP AFSPVMNYKD GVSSETVTAL GMMESPVVSM 900
VPTHLTEFRM EVEDGLGSPK PEEIKDFSYV HKVPQFQPFV GSSMFAPLKT LPSHCLLPLK 960
TPDACLFRPS WAVPPKMEQL PMPPAASSIR DGYNNVPSVG SLADPDYLNT PQMNTPVTLN 1020
SAAPASNSGA GVLPSPATPR FSVPTPRTPR TPRTPRGGGT ASGQGSVKYD STDQGSPAST 1080
PSTTRPLNSV EPATMQPIPE AHSLYVTLIL SDSVMNVFKD RNFDSCCICA CNMNIKGADV 1140
GLYIPDSSKE DQYRCTCGFS AIVNRKLGYN SGLFLEDELD IFGKNSDIGQ AAERRLMMCQ 1200
SSGQSTLLPQ VEGARKAPEP PVSLLLLLQN QHTQPFASLS FLDYISSANR HALPCVSWTY 1260
DRVQADNNDY WTECFNALEQ GRQYVDNPTG GKVDEALVRS ATVHCWPHSN VLDTSMLSSQ 1320
DVVRMLLSLQ PFLQDAIQKK RTGRTWENIQ HVQGPLTWQQ FHKMAGRGTY GSEESPEPLP 1380
IPTLLVGYDK EFLTISPFSL PFWERLLLEP YGGHRDVAYI VVCPENEALL EGAKTFFRDL 1440
SAVYEMCRLG QHKPICKVLR DGIMRVGKTV AQKLTEELVS EWFNQPWSSE ESDNHSRLKL 1500
YAQVCRHHLA PYLATLQLDS GLLMPPKHQS PPAEAQGQAT PGNAGSLPSN SGSGAPPAGS 1560
AFNPTSSSSA NPTTSSSSAS SGPPGSSAAS APGITQMNTT SSSGFGGGVG GQNPSAGGSS 1620
TDRTPGNVAC GDTEPGQSCT QSSQDGQDSV TERERIGIPT EPDSADSHAY PPAVVIYMVD 1680
PFTYTAEEDS SSGNFWLLSL MRCYTEMLDH LPEHMRSSFI LQIVPCQYML QTMKDEHVFY 1740
IQYLKSMAFS VYCQCRRPLP TQIHIKSLTG FGPAASIEMT LKNPERPSPI QLYSPPFILA 1800
PIKDKQTEPG ETFGEASQKY NVLFVGYCLS HDQRWLLASC TDLHGELLET CVVNIALPSR 1860
SRKSKVSARK VGLQKLWEWC LGIVQMTSLP WRVVIGRLGR LGHGELKDWS ILLGECSLQT 1920
ISKQLKDVCR MCGISAADSP SILSACLVAM EPQGSFVVMP DAVTMGSVFG RSTALNMQSS 1980
QLNTPQDASC THILVFPTSS TIQVAPANYP NEDGFSPNND DMFVDLPFPD DMDNDIGILM 2040
TGNLHSSPNS SPVPSPGSPS GIGVGSHFQH SRSQGERLLS REAPEELKQQ PLALGYFVST 2100
AKAENLPQWF WSSCPQARNQ CPLFLKASLH HHISVAQTDE LLPARTSQRA PHPLDSKTTS 2160
DVLRFVLEQY NALSWLTCNP ATQDRTSCLP VHFVVLTQLY NAIMNML 2207 
Gene Ontology
 GO:0016592; C:mediator complex; IDA:MGI.
 GO:0001104; F:RNA polymerase II transcription cofactor activity; IEA:InterPro.
 GO:0006366; P:transcription from RNA polymerase II promoter; IC:MGI. 
Interpro
 IPR009401; Mediator_Med13.
 IPR021643; Mediator_Med13_N_met/fun. 
Pfam
 PF06333; Med13_C
 PF11597; Med13_N 
SMART
  
PROSITE
  
PRINTS