UniProt Accession

 NCB2_YEAST; Q92317; D6VT30; O00064; P87340; Q04176 

Genbank Protein ID

 U91948; Y09266; U32274; BK006938 

Genbank Nucleotide ID

 AAB51375.1; CAA70461.1; AAB64838.1; DAA12240.1 

Protein Name

 Negative cofactor 2 complex subunit beta 

Protein Synonyms/Alias

 NC2 complex subunit beta; Transcriptional repressor YDR1 

Gene Name

 NCB2 

Gene Synonyms/Alias

 YDR1; YDR397C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
141	NSVSDPVKSEDSS**	sumoylation	[1]

Reference

 [1] Stimulation of in vitro sumoylation by Slx5-Slx8: evidence for a functional interaction with the SUMO pathway.
 Ii T, Mullen JR, Slagle CE, Brill SJ.
 DNA Repair (Amst). 2007 Nov;6(11):1679-91. [PMID: 17669696] 

Functional Description

 Component of the NC2 complex which represses RNA polymerase II transcription through binding to SPT15/TBP and thereby inhibiting the assembly of the preinitiation complex. The NC2 complex may also mediate transcriptional activation from TATA- driven promoters through association with SPT15/TBP. 

Sequence Annotation

 MOD_RES 135 135 Phosphoserine.
 MOD_RES 137 137 Phosphoserine.
 MOD_RES 142 142 Phosphoserine.  

Keyword

 Activator; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 146 AA 

Protein Sequence

Gene Ontology

 GO:0017054; C:negative cofactor 2 complex; IDA:SGD.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003713; F:transcription coactivator activity; IDA:SGD.
 GO:0003714; F:transcription corepressor activity; IGI:SGD.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IGI:SGD.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:SGD.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR003958; CBFA_NFYB_domain.
 IPR027113; Dr1/Ncb2.
 IPR009072; Histone-fold. 

Pfam

 PF00808; CBFD_NFYB_HMF 

SMART

  

PROSITE

  

PRINTS