UniProt Accession

 ERR2_HUMAN; O95718; A2VDJ2; B6ZGU4; Q5F0P7; Q5F0P8; Q9HCB4 

Genbank Protein ID

 AF094517; AY451389; AY451390; AB307714; HQ692852; AC008050; AC016543; BC131517 

Genbank Nucleotide ID

 AAC99409.1; AAS15571.1; AAS15572.1; BAH02305.1; ADZ17363.1; AAG17472.1; AAI31518.1 

Protein Name

 Steroid hormone receptor ERR2 

Protein Synonyms/Alias

 ERR beta-2; Estrogen receptor-like 2; Estrogen-related receptor beta; ERR-beta; Nuclear receptor subfamily 3 group B member 2 

Gene Name

 ESRRB 

Gene Synonyms/Alias

 ERRB2; ESRL2; NR3B2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
238	GMPEGDIKALTTLCD	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Nuclear receptor, may regulate ESR1 transcriptional activity. 

Sequence Annotation

 DNA_BIND 100 186 Nuclear receptor.
 ZN_FING 103 123 NR C4-type.
 ZN_FING 139 163 NR C4-type.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Deafness; Disease mutation; DNA-binding; Metal-binding; Non-syndromic deafness; Nucleus; Receptor; Reference proteome; Transcription; Transcription regulation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 508 AA 

Protein Sequence

Gene Ontology

 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0004879; F:ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; TAS:ProtInc.
 GO:0000980; F:RNA polymerase II distal enhancer sequence-specific DNA binding; ISS:BHF-UCL.
 GO:0005496; F:steroid binding; IEA:InterPro.
 GO:0003707; F:steroid hormone receptor activity; IEA:InterPro.
 GO:0003713; F:transcription coactivator activity; ISS:BHF-UCL.
 GO:0008134; F:transcription factor binding; ISS:BHF-UCL.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:BHF-UCL.
 GO:0019827; P:stem cell maintenance; IEA:Compara.
 GO:0006367; P:transcription initiation from RNA polymerase II promoter; TAS:Reactome.
 GO:0001834; P:trophectodermal cell proliferation; IEA:Compara.
 GO:0001831; P:trophectodermal cellular morphogenesis; IEA:Compara. 

Interpro

 IPR008946; Nucl_hormone_rcpt_ligand-bd.
 IPR000536; Nucl_hrmn_rcpt_lig-bd_core.
 IPR027289; Oest-rel_rcp.
 IPR024178; Oest_rcpt/oest-rel_rcp.
 IPR001723; Str_hrmn_rcpt.
 IPR001628; Znf_hrmn_rcpt.
 IPR013088; Znf_NHR/GATA. 

Pfam

 PF00104; Hormone_recep
 PF00105; zf-C4 

SMART

 SM00430; HOLI
 SM00399; ZnF_C4 

PROSITE

 PS00031; NUCLEAR_REC_DBD_1
 PS51030; NUCLEAR_REC_DBD_2 

PRINTS

 PR00398; STRDHORMONER.
 PR00047; STROIDFINGER.