| Tag | Content |
|---|
| CPLM ID | CPLM-016056 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Tectonin beta-propeller repeat-containing protein 1 |
Protein Synonyms/Alias | |
Gene Name | Tecpr1 |
Gene Synonyms/Alias | Kiaa1358 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 36 | KDVQLEFKRVSAATQ | ubiquitination | [1] | | 585 | AQTAAWRKQIFQQLT | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation (By similarity). |
Sequence Annotation | REPEAT 209 240 TECPR 1.
REPEAT 254 285 TECPR 2.
REPEAT 301 332 TECPR 3.
REPEAT 344 376 TECPR 4.
DOMAIN 616 722 PH.
REPEAT 734 761 TECPR 5.
REPEAT 958 989 TECPR 6.
REPEAT 1003 1034 TECPR 7.
REPEAT 1049 1080 TECPR 8.
REPEAT 1092 1132 TECPR 9.
MOD_RES 943 943 Phosphoserine (By similarity). |
Keyword | Alternative splicing; Autophagy; Complete proteome; Cytoplasmic vesicle; Lipid-binding; Lysosome; Membrane; Phosphoprotein; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1166 AA |
Protein Sequence | MPTSVLWAVD LFGRVYTLST AGQYWELCKD VQLEFKRVSA ATQCCWGIAG DNQVYLYVCS 60
SDVPIRHREE AYENQRWNPM GGFCEKLLPS DRWPWSDVSG LQHRPLDGVA LPSPHWEWES 120
DWYVDENFGG EPTEKGGWTY AMDFPATYTR DKKWNSCVRR RKWIRYRRYK SRDSWAKIPS 180
KDDPKELPDP FNDLSVGGWE ITEEPVGRLS VWAVSLQGKV WYREDVSHPN PEGSSWSLVE 240
TPGEVVQISC GPHDLIWATL WEGQALVREG VCRNNPKGSY WSMVEPPGSE NGIMHVSAGV 300
SVVWAITKDR KVWFRRGVNS HNPCGTSWIE MVGEMTMVNV GLNDQVWGIS CEDRAVYFRQ 360
GVTPSELSGK TWKAIVVGRE SDRSHSGSSS SLLSAGCFFG DEVRGSGTES APSDTDASLE 420
VERQGPEQPL PKEALDNSTN LKGSLSKGHE TSGNTDHSTE NACLTEGKEK APETSRSDEC 480
RGPASTPAEL PWTNIDLKEP KKVSNQPAAG FPETAGLSSL GLFPMGMEEP YGADDHPLWA 540
WVSGGACAVE AGSTLKWFTI QSGLSPSVQT LSLSITPAQT AAWRKQIFQQ LTERTKRELE 600
SFRHYEQAVE QSVWVKTGAL QWWCDWKPHK WVDVRVALEQ FTGHDGARDS ILFIYYVVHE 660
EKKYLHVFLN EVTVLVPVLN EAKHSFALYT PERTRQRWPV RLAAATEQDM NDWLALLSLS 720
CCESRKVHGR PSPQAIWSVT CKGDIFVSEP SPDLEARERL LPCDQMFWRQ MGGHLRIIEA 780
NSRGVVWGIG YDHTAWVYTG GYGGGCFQGL ASSTSNIYTQ SDVKSVYIYE NQRWNPVTGY 840
TSRGLPTDRF MWSDVTGLQE CTKAGTKPPS LQWTWVSDWY VDFSVPGGTD QEGWQYASDF 900
PASYHGYKTM KDFVRRRCWA RKCKLVTSGP WLEVAPITLS DVSIIPESAH ADGRGHNVAL 960
WAVSDKGDVL CRLGVSELNP AGSSWLHVGT DQPFASVSIG ACYQVWAVAR DGSAFYRGSV 1020
SPSQPAGDCW YHIPSPPKQK LTQVSVGQTS VYALDENGNL WYRAGITPSY PQGSSWEHVS 1080
NNVRKVSVGP LDQVWVIANK VQGSHGLSRG TVCRRMGVQP REPKGQGWDY GIGGGWDHIS 1140
VRANATRVPR NMSRDREARG PGPVCC 1166 |
Gene Ontology | GO:0000421; C:autophagic vacuole membrane; ISS:UniProtKB. GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW. GO:0016021; C:integral to membrane; IEA:InterPro. GO:0005765; C:lysosomal membrane; ISS:UniProtKB. GO:0032266; F:phosphatidylinositol-3-phosphate binding; ISS:UniProtKB. GO:0000046; P:autophagic vacuole fusion; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |