UniProt Accession

 VEZF1_HUMAN; Q14119 

Genbank Protein ID

 D28118; AC015813 

Genbank Nucleotide ID

 BAA05663.1 

Protein Name

 Vascular endothelial zinc finger 1 

Protein Synonyms/Alias

 Putative transcription factor DB1; Zinc finger protein 161 

Gene Name

 VEZF1 

Gene Synonyms/Alias

 DB1; ZNF161 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
181	HACEMCGKAFRDVYH	ubiquitination	[1]
273	CTAAFATKDRLRTHM	ubiquitination	[1]
325	TCKQGISKTCMSEET	ubiquitination	[1]
362	HVTSWPGKQVETLRL	ubiquitination	[2, 3]
375	RLWEEAVKARKKEAA	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Possible transcription factor. Specifically binds to the CT/GC-rich region of the interleukin-3 promoter and mediates tax transactivation of IL-3. 

Sequence Annotation

 REPEAT 394 400 1.
 REPEAT 445 451 2.
 REPEAT 457 463 3.
 REPEAT 479 485 4.
 ZN_FING 74 96 C2H2-type 1.
 ZN_FING 174 196 C2H2-type 2.
 ZN_FING 202 224 C2H2-type 3.
 ZN_FING 232 255 C2H2-type 4.
 ZN_FING 261 283 C2H2-type 5.
 ZN_FING 287 308 C2H2-type 6.
 REGION 394 485 4 X 7 AA repeats of P-[LV]-T-[IL]-T-[ST]-
 MOD_RES 362 362 N6-acetyllysine.  

Keyword

 Acetylation; Activator; Complete proteome; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 521 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IDA:HPA.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0001525; P:angiogenesis; IEA:Compara.
 GO:0006968; P:cellular defense response; TAS:ProtInc.
 GO:0001885; P:endothelial cell development; IEA:Compara.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; TAS:ProtInc.
 GO:0006366; P:transcription from RNA polymerase II promoter; TAS:ProtInc. 

Interpro

 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 

Pfam

 PF00096; zf-C2H2 

SMART

 SM00355; ZnF_C2H2 

PROSITE

 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 

PRINTS