UniProt Accession

 G3V2M8_HUMAN; G3V2M8 

Genbank Protein ID

 AL121852 

Genbank Nucleotide ID

  

Protein Name

 Sec1 family domain-containing protein 1 

Protein Synonyms/Alias

  

Gene Name

 SCFD1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
38	ISPLLSVKELRDMGI	ubiquitination	[1, 2, 3, 4, 5]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 198 AA 

Protein Sequence

Gene Ontology

 GO:0017119; C:Golgi transport complex; IEA:Compara.
 GO:0005798; C:Golgi-associated vesicle; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0006892; P:post-Golgi vesicle-mediated transport; IEA:Compara.
 GO:0060628; P:regulation of ER to Golgi vesicle-mediated transport; IEA:Compara.
 GO:0001666; P:response to hypoxia; IEA:Compara.
 GO:0006890; P:retrograde vesicle-mediated transport, Golgi to ER; IEA:Compara.
 GO:0006904; P:vesicle docking involved in exocytosis; IEA:InterPro. 

Interpro

 IPR027482; Sec-1-like_dom2.
 IPR001619; Sec1-like. 

Pfam

 PF00995; Sec1 

SMART

  

PROSITE

  

PRINTS