UniProt Accession

 MOD5_HUMAN; Q9H3H1; A1A4X7; Q5QPK5; Q5QPK6; Q6IAC9; Q96FJ3; Q96L45; Q9NXT7 

Genbank Protein ID

 AF074918; AY303390; AK000068; CR457226; AL033527; AL033527; BC010741; BC107569; BC128155; AY052768 

Genbank Nucleotide ID

 AAG31324.1; AAP60111.1; BAA90923.1; CAG33507.1; CAI19405.1; CAI19406.1; AAH10741.2; AAI07570.1; AAI28156.1; AAL14107.1 

Protein Name

 tRNA dimethylallyltransferase, mitochondrial 

Protein Synonyms/Alias

 Isopentenyl-diphosphate:tRNA isopentenyltransferase; IPP transferase; IPPT; hGRO1; tRNA isopentenyltransferase; IPTase 

Gene Name

 TRIT1 

Gene Synonyms/Alias

 IPT; MOD5 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
138	WKVLVNTKPQEMGTE	ubiquitination	[1]
146	PQEMGTEKVIDRKVE	ubiquitination	[1]
176	VDPEMAAKLHPHDKR	ubiquitination	[1]
391	PYNEAENKRSYHLCD	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A). 

Sequence Annotation

 ZN_FING 395 425 Matrin-type.
 REGION 32 37 Substrate binding (By similarity).
 REGION 55 58 Interaction with substrate tRNA (By
 REGION 183 187 Interaction with substrate tRNA (By
 REGION 233 255 Interaction with isopentenylpyrophosphate
 REGION 281 283 Interaction with substrate tRNA (By
 REGION 313 331 Interaction with substrate tRNA (By
 REGION 323 330 Interaction with substrate tRNA (By
 MOD_RES 455 455 Phosphoserine.  

Keyword

 Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Metal-binding; Mitochondrion; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Transferase; Transit peptide; tRNA processing; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 467 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0052381; F:tRNA dimethylallyltransferase activity; TAS:UniProtKB.
 GO:0008033; P:tRNA processing; NAS:UniProtKB. 

Interpro

 IPR002627; IPPT.
 IPR027417; P-loop_NTPase.
 IPR018022; tRNA_delta_PyrP_Trfase.
 IPR022755; Znf_C2H2_jaz. 

Pfam

 PF01715; IPPT
 PF12171; zf-C2H2_jaz 

SMART

  

PROSITE

 PS50171; ZF_MATRIN 

PRINTS