CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044805
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 PDZ domain-containing protein GIPC1 
Protein Synonyms/Alias
  
Gene Name
 GIPC1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
31DFIFAHVKGQRKEVEubiquitination[1, 2, 3]
102YEVARLLKELPRGRTubiquitination[3, 4]
113RGRTFTLKLTEPRKAubiquitination[1, 3]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 121 AA 
Protein Sequence
MFCTLNTHKV DMDKLLGGQI GLEDFIFAHV KGQRKEVEVF KSEDALGLTI TDNGAGYAFI 60
KRIKEGSVID HIHLISVGDM IEAINGQSLL GCRHYEVARL LKELPRGRTF TLKLTEPRKA 120
F 121 
Gene Ontology
 GO:0005903; C:brush border; IEA:Compara.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0043198; C:dendritic shaft; IEA:Compara.
 GO:0043197; C:dendritic spine; IEA:Compara.
 GO:0030139; C:endocytic vesicle; IEA:Compara.
 GO:0008021; C:synaptic vesicle; IEA:Compara.
 GO:0012506; C:vesicle membrane; IEA:Compara.
 GO:0043542; P:endothelial cell migration; IEA:Compara.
 GO:0014047; P:glutamate secretion; IEA:Compara.
 GO:0032435; P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Compara.
 GO:0030511; P:positive regulation of transforming growth factor beta receptor signaling pathway; IEA:Compara.
 GO:0006605; P:protein targeting; IEA:Compara.
 GO:0031647; P:regulation of protein stability; IEA:Compara.
 GO:0048167; P:regulation of synaptic plasticity; IEA:Compara.
 GO:0007268; P:synaptic transmission; IEA:Compara. 
Interpro
 IPR001478; PDZ. 
Pfam
 PF00595; PDZ 
SMART
 SM00228; PDZ 
PROSITE
 PS50106; PDZ 
PRINTS