CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005354
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Necdin 
Protein Synonyms/Alias
  
Gene Name
 Ndn 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
72RIEDVDPKILQQAAEubiquitination[1]
237STFGDVRKIITEEFVubiquitination[1]
250FVQQNYLKYQRVPHIubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle- promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Functions also as transcription factor and binds directly to specific guanosine-rich DNA sequences. 
Sequence Annotation
 DOMAIN 102 301 MAGE.  
Keyword
 Complete proteome; Cytoplasm; DNA-binding; Growth regulation; Nucleus; Polymorphism; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 325 AA 
Protein Sequence
MSEQSKDLSD PNFAAEVPDC EMQDSDAVPV GIPPPASLAA NLAGPPCAPE GPMAAQQASP 60
PPEERIEDVD PKILQQAAEE GRAHQPQSPA RPIPAPPAPA QLVQKAHELM WYVLVKDQKR 120
MVLWFPDMVK EVMGSYKKWC RSILRRTSVI LARVFGLHLR LTNLHTMEFA LVKALSPEEL 180
DRVALNNRMP MTGLLLMILS LIYVKGRGAR EGAVWNVLRI LGLRPWKKHS TFGDVRKIIT 240
EEFVQQNYLK YQRVPHIEPP EYEFFWGSRA NREITKMQIM EFLARVFKKD PQAWPSRYRE 300
ALEQARALRE ANLAAQAPRS SVSED 325 
Gene Ontology
 GO:0042995; C:cell projection; IDA:MGI.
 GO:0005813; C:centrosome; IDA:MGI.
 GO:0005829; C:cytosol; IDA:MGI.
 GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell.
 GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0043015; F:gamma-tubulin binding; IDA:MGI.
 GO:0048675; P:axon extension; IMP:MGI.
 GO:0007413; P:axonal fasciculation; IMP:MGI.
 GO:0006874; P:cellular calcium ion homeostasis; TAS:MGI.
 GO:0007417; P:central nervous system development; IMP:MGI.
 GO:0071514; P:genetic imprinting; IMP:MGI.
 GO:0008347; P:glial cell migration; IMP:MGI.
 GO:0048871; P:multicellular organismal homeostasis; IMP:MGI.
 GO:0001764; P:neuron migration; IMP:MGI.
 GO:0048011; P:neurotrophin TRK receptor signaling pathway; IMP:MGI.
 GO:0009791; P:post-embryonic development; IMP:MGI.
 GO:0001558; P:regulation of cell growth; TAS:MGI.
 GO:0006355; P:regulation of transcription, DNA-dependent; IGI:MGI.
 GO:0003016; P:respiratory system process; IMP:MGI.
 GO:0019233; P:sensory perception of pain; IMP:MGI.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR002190; MAGE. 
Pfam
 PF01454; MAGE 
SMART
  
PROSITE
 PS50838; MAGE 
PRINTS