CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037013
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Axin-2 
Protein Synonyms/Alias
  
Gene Name
 AXIN2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
528HHAVPKTKEEIEAEAubiquitination[1]
773YEGRILGKVERID**ubiquitination[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 778 AA 
Protein Sequence
MSSAMLVTCL PDPSSSFRED APRPPVPGEE GETPPCQPGV GKGQVTKPMP VSSNTRRNED 60
GLGEPEGRAS PDSPLTRWTK SLHSLLGDQD GAYLFRTFLE REKCVDTLDF WFACNGFRQM 120
NLKDTKTLRV AKAIYKRYIE NNSIVSKQLK PATKTYIRDG IKKQQIDSIM FDQAQTEIQS 180
VMEENAYQMF LTSDIYLEYV RSGGENTAYM SNGGLGSLKV VCGYLPTLNE EEEWTCADFK 240
CKLSPTVVGL SSKTLRATAS VRSTETVDSG YRSFKRSDPV NPYHIGSGYV FAPATSANDS 300
EISSDALTDD SMSMTDSSVD GIPPYRVGSK KQLQREMHRS VKANGQVSLP HFPRTHRLPK 360
EMTPVEPATF AAELISRLEK LKLELESRHS LEERLQQIRE DEEREGSELT LNSREGAPTQ 420
HPLSLLPSGS YEEDPQTILD DHLSRVLKTP GCQSPGVGRY SPRSRSPDHH HHHHSQYHSL 480
LPPGGKLPPA AASPGACPLL GGKGFVTKQT TKHVHHHYIH HHAVPKTKEE IEAEATQRVH 540
CFCPGGSEYY CYSKCKSHSK APETMPSEQF GAQSTKKAYP LESARSSPGE RASRHHLWGG 600
NSGHPRTTPR AHLFTQDPAM PPLTPPNTLA QLEEACRRLA EVSKPPKQRC CVASQQRDRN 660
HSATVQTGAT PFSNPSLAPE DHKEPKKLAG VHALQASELV VTYFFCGEEI PYRRMLKAQS 720
LTLGHFKEQL SKKGNYRYYF KKASDEFACG AVFEEIWEDE TVLPMYEGRI LGKVERID 778 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0004871; F:signal transducer activity; IEA:InterPro.
 GO:0007275; P:multicellular organismal development; IEA:InterPro.
 GO:0007165; P:signal transduction; IEA:GOC.
 GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro. 
Interpro
 IPR014936; Axin_b-cat-bd.
 IPR001158; DIX.
 IPR000342; Regulat_G_prot_signal.
 IPR024066; Regulat_G_prot_signal_dom1.
 IPR016137; Regulat_G_prot_signal_superfam. 
Pfam
 PF08833; Axin_b-cat_bind
 PF00778; DIX
 PF00615; RGS 
SMART
 SM00021; DAX
 SM00315; RGS 
PROSITE
 PS50841; DIX
 PS50132; RGS 
PRINTS
 PR01301; RGSPROTEIN.