CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040650
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Bromodomain adjacent to zinc finger domain protein 2A 
Protein Synonyms/Alias
  
Gene Name
 BAZ2A 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
593KQFPEVIKYLSRNVVubiquitination[1]
685KITELLNKTDNRPLKacetylation[2]
705ETLNEEDKAKIAKSKacetylation[2]
1004MSSYRKNKWIVEGRLacetylation[3]
1674AWEKSVNKVTCLVCRubiquitination[4]
1899WEEFYQGKQANL***ubiquitination[1, 5]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 Bromodomain; Complete proteome; Metal-binding; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1903 AA 
Protein Sequence
MEANDHFNFT GLPPAPAASG LKPSPSSGEG LYTNGSPMNF PQQGKSLNGD VNVNGLSTVS 60
HTTTSGILNS APHSSSTSHL HHPSVAYDCL WNYSQYPSAN PGSNLKDPPL LSQFSGGQYP 120
LNGILGGSRQ PSSPSHNTNL RAGSQEFWAN GTQSPMGLNF DSQELYDSFP DQNFEVMPNG 180
PPSFFTSPQT SPMLGSSIQT FAPSQEVGSG IHPDEAAEKE MTSVVAENGT GLVGSLELEE 240
EQPELKMCGY NGSVPSVESL HQEVSVLVPD PTVSCLDDPS HLPDQLEDTP ILSEDSLEPF 300
NSLAPEPVSG GLYGIDDTEL MGAEDKLPLE DSPVISALDC PSLNNATAFS LLADDSQTST 360
SIFASPTSPP VLGESVLQDN SFDLNNGSDA EQEEMETQSS DFPPSLTQPA PDQSSTIQLH 420
PATSPAVSPT TSPAVSLVVS PAASPEISPE VCPAASTVVS PAVFSVVSPA SSAVLPAVSL 480
EVPLTASVTS PKASPVTSPA AAFPTASPAN KDVSSFLETT ADVEEITGEG LTASGSGDVM 540
RRRIATPEEV RLPLQHGWRR EVRIKKGSHR WQGETWYYGP CGKRMKQFPE VIKYLSRNVV 600
HSVRREHFSF SPRMPVGDFF EERDTPEGLQ WVQLSAEEIP SRIQAITGKR GRPRNTEKAK 660
TKEVPKVKRG RGRPPKVKIT ELLNKTDNRP LKKLEAQETL NEEDKAKIAK SKKKMRQKVQ 720
RGECQTTIQG QARNKRKQET KSLKQKEAKK KSKAEKEKGK TKQEKLKEKV KREKKEKVKM 780
KEKEEVTKAK PACKADKTLA TQRRLEERQR QQMILEEMKK PTEDMCLTDH QPLPDFSRVP 840
GLTLPSGAFS DCLTIVEFLH SFGKVLGFDP AKDVPSLGVL QEGLLCQGDS LGEVQDLLVR 900
LLKAALHDPG FPSYCQSLKI LGEKVSEIPL TRDNVSEILR CFLMAYGVEP ALCDRLRTQP 960
FQAQPPQQKA AVLAFLVHEL NGSTLIINEI DKTLESMSSY RKNKWIVEGR LRRLKTVLAK 1020
RTGRSEVEME GPEECLGRRR SSRIMEETSG MEEEEEEESI AAVPGRRGRR DGEVDATASS 1080
IPELERQIEK LSKRQLFFRK KLLHSSQMLR AVSLGQDRYR RRYWVLPYLA GIFVEGTEGN 1140
LVPEEVIKKE TDSLKVAAHA SLNPALFSMK MELAGSNTTA SSPARARGRP RKTKPGSMQP 1200
RHLKSPVRGQ DSEQPQAQLQ PEAQLHAPAQ PQPQLQLQLQ SHKGFLEQEG SPLSLGQSQH 1260
DLSQSAFLSW LSQTQSHSSL LSSSVLTPDS SPGKLDPAPS QPPEEPEPDE AESSPDPQAL 1320
WFNISAQMPC NAAPTPPPAV SEDQPTPSPQ QLASSKPMNR PSAANPCSPV QFSSTPLAGL 1380
APKRRAGDPG EMPQSPTGLG QPKRRGRPPS KFFKQMEQRY LTQLTAQPVP PEMCSGWWWI 1440
RDPEMLDAML KALHPRGIRE KALHKHLNKH RDFLQEVCLR PSADPIFEPR QLPAFQEGIM 1500
SWSPKEKTYE TDLAVLQWVE ELEQRVIMSD LQIRGWTCPS PDSTREDLAY CEHLSDSQED 1560
ITWRGRGREG LAPQRKTTNP LDLAVMRLAA LEQNVERRYL REPLWPTHEV VLEKALLSTP 1620
NGAPEGTTTE ISYEITPRIR VWRQTLERCR SAAQVCLCLG QLERSIAWEK SVNKVTCLVC 1680
RKGDNDEFLL LCDGCDRGCH IYCHRPKMEA VPEGDWFCTV CLAQQVEGEF TQKPGFPKRG 1740
QKRKSGYSLN FSEGDGRRRR VLLRGRESPA AGPRYSEEGL SPSKRRRLSM RNHHSDLTFC 1800
EIILMEMESH DAAWPFLEPV NPRLVSGYRR IIKNPMDFST MRERLLRGGY TSSEEFAADA 1860
LLVFDNCQTF NEDDSEVGKA GHIMRRFFES RWEEFYQGKQ ANL 1903 
Gene Ontology
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0003677; F:DNA binding; IEA:Compara.
 GO:0003723; F:RNA binding; IEA:Compara.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0000183; P:chromatin silencing at rDNA; IEA:Compara.
 GO:0070869; P:heterochromatin assembly involved in chromatin silencing; IEA:Compara.
 GO:0051567; P:histone H3-K9 methylation; IEA:Compara.
 GO:0070933; P:histone H4 deacetylation; IEA:Compara.
 GO:0034770; P:histone H4-K20 methylation; IEA:Compara. 
Interpro
 IPR017956; AT_hook_DNA-bd_motif.
 IPR001487; Bromodomain.
 IPR018359; Bromodomain_CS.
 IPR004022; DDT_dom.
 IPR018500; DDT_dom_subgr.
 IPR018501; DDT_dom_superfamily.
 IPR016177; DNA-bd_integrase-typ.
 IPR001739; Methyl_CpG_DNA-bd.
 IPR011011; Znf_FYVE_PHD.
 IPR001965; Znf_PHD.
 IPR019787; Znf_PHD-finger.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF00439; Bromodomain
 PF02791; DDT
 PF01429; MBD
 PF00628; PHD 
SMART
 SM00384; AT_hook
 SM00297; BROMO
 SM00571; DDT
 SM00391; MBD
 SM00249; PHD 
PROSITE
 PS00633; BROMODOMAIN_1
 PS50014; BROMODOMAIN_2
 PS50827; DDT
 PS50982; MBD
 PS50016; ZF_PHD_2 
PRINTS
 PR00503; BROMODOMAIN.