UniProt Accession

 PGES2_MOUSE; Q8BWM0; A2ASQ2; Q99J30 

Genbank Protein ID

 AK050616; AL928669; CH466542; BC004846 

Genbank Nucleotide ID

 BAC34345.1; CAM22503.1; EDL08547.1; AAH04846.1 

Protein Name

 Prostaglandin E synthase 2 

Protein Synonyms/Alias

 GATE-binding factor 1; GBF-1; Microsomal prostaglandin E synthase 2; mPGES-2; Prostaglandin E synthase 2 truncated form 

Gene Name

 Ptges2 

Gene Synonyms/Alias

 Gbf1; Pges2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
140	PVRRTEIKFSSYRKV	ubiquitination	[1]
232	EARTEEMKWRQWADD	acetylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 Isomerase that catalyzes the conversion of unstable intermediate of prostaglandin E2 H2 (PGH2) into the more stable prostaglandin E2 (PGE2) form (By similarity). May also have transactivation activity toward IFN-gamma (IFNG), possibly via an interaction with CEBPB; however, the relevance of transcription activation activity remains unclear. 

Sequence Annotation

 DOMAIN 89 192 Glutaredoxin.
 DOMAIN 262 376 GST C-terminal.
 REGION 163 164 Glutathione binding (By similarity).
 BINDING 147 147 Glutathione; via amide nitrogen and  

Keyword

 Complete proteome; Cytoplasm; Fatty acid biosynthesis; Fatty acid metabolism; Golgi apparatus; Isomerase; Lipid biosynthesis; Lipid metabolism; Membrane; Nucleus; Prostaglandin biosynthesis; Prostaglandin metabolism; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 384 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:MGI.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0003677; F:DNA binding; IDA:MGI.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0050220; F:prostaglandin-E synthase activity; IEA:EC.
 GO:0015035; F:protein disulfide oxidoreductase activity; IEA:InterPro.
 GO:0045454; P:cell redox homeostasis; IEA:InterPro.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:MGI.
 GO:0001516; P:prostaglandin biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0046903; P:secretion; IDA:MGI. 

Interpro

 IPR002109; Glutaredoxin.
 IPR010987; Glutathione-S-Trfase_C-like.
 IPR012336; Thioredoxin-like_fold. 

Pfam

  

SMART

  

PROSITE

 PS00195; GLUTAREDOXIN_1
 PS51354; GLUTAREDOXIN_2
 PS50405; GST_CTER 

PRINTS