CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010502
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Guanine nucleotide-binding protein G(q) subunit alpha 
Protein Synonyms/Alias
 Guanine nucleotide-binding protein alpha-q 
Gene Name
 Gnaq 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
102DTLKIPYKYEHNKAHubiquitination[1]
158YQLSDSTKYYLNDLDubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. 
Sequence Annotation
 NP_BIND 46 53 GTP (By similarity).
 NP_BIND 180 186 GTP (By similarity).
 NP_BIND 205 209 GTP (By similarity).
 NP_BIND 274 277 GTP (By similarity).
 METAL 53 53 Magnesium (By similarity).
 METAL 186 186 Magnesium (By similarity).
 BINDING 331 331 GTP; via amide nitrogen (By similarity).
 LIPID 9 9 S-palmitoyl cysteine (By similarity).
 LIPID 10 10 S-palmitoyl cysteine (By similarity).  
Keyword
 Complete proteome; GTP-binding; Lipoprotein; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Nucleus; Palmitate; Reference proteome; Transducer. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 359 AA 
Protein Sequence
MTLESIMACC LSEEAKEARR INDEIERQLR RDKRDARREL KLLLLGTGES GKSTFIKQMR 60
IIHGSGYSDE DKRGFTKLVY QNIFTAMQAM VRAMDTLKIP YKYEHNKAHA QLVREVDVEK 120
VSAFENPYVD AIKSLWNDPG IQECYDRRRE YQLSDSTKYY LNDLDRVADP SYLPTQQDVL 180
RVRVPTTGII EYPFDLQSVI FRMVDVGGQR SERRKWIHCF ENVTSIMFLV ALSEYDQVLV 240
ESDNENRMEE SKALFRTIIT YPWFQNSSVI LFLNKKDLLE EKIMYSHLVD YFPEYDGPQR 300
DAQAAREFIL KMFVDLNPDS DKIIYSHFTC ATDTENIRFV FAAVKDTILQ LNLKEYNLV 359 
Gene Ontology
 GO:0005901; C:caveola; IDA:RGD.
 GO:0005829; C:cytosol; IDA:RGD.
 GO:0005834; C:heterotrimeric G-protein complex; IBA:RefGenome.
 GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
 GO:0031683; F:G-protein beta/gamma-subunit complex binding; IBA:RefGenome.
 GO:0005525; F:GTP binding; IDA:RGD.
 GO:0005096; F:GTPase activator activity; IBA:RefGenome.
 GO:0003924; F:GTPase activity; IBA:RefGenome.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004871; F:signal transducer activity; IBA:RefGenome.
 GO:0031826; F:type 2A serotonin receptor binding; IMP:RGD.
 GO:0007202; P:activation of phospholipase C activity; IMP:RGD.
 GO:0007189; P:adenylate cyclase-activating G-protein coupled receptor signaling pathway; IBA:RefGenome.
 GO:0007215; P:glutamate receptor signaling pathway; IBA:RefGenome.
 GO:0043066; P:negative regulation of apoptotic process; IMP:RGD.
 GO:0043267; P:negative regulation of potassium ion transport; IMP:RGD.
 GO:0060158; P:phospholipase C-activating dopamine receptor signaling pathway; IBA:RefGenome.
 GO:0043065; P:positive regulation of apoptotic process; TAS:RGD.
 GO:0048661; P:positive regulation of smooth muscle cell proliferation; IMP:RGD.
 GO:0001508; P:regulation of action potential; IBA:RefGenome. 
Interpro
 IPR000654; Gprotein_alpha_Q.
 IPR001019; Gprotein_alpha_su.
 IPR011025; GproteinA_insert.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00503; G-alpha 
SMART
 SM00275; G_alpha 
PROSITE
  
PRINTS
 PR00318; GPROTEINA.
 PR00442; GPROTEINAQ.