CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038559
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Ogdhl 
Protein Synonyms/Alias
  
Gene Name
 Ogdhl 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
282ARKWSSEKRFGLEGCacetylation[1, 2]
857QILLPFRKPLIVFTPacetylation[3, 4]
857QILLPFRKPLIVFTPsuccinylation[4]
919KVYYDLVKERSSQGLubiquitination[5]
Reference
 [1] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [2] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [5] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1029 AA 
Protein Sequence
MSQLRLLPFR LGPRATKLLA TRAIPVFSGC RRSSGPPTTI PRSRSGVSSS YVEEMYFAWL 60
ENPQSVHKSW DSFFQRASKE ASVGPAQPQL PAVLQESRTS VSSCTKTSKL VEDHLAVQSL 120
IRAYQIRGHH VAQLDPLGIL DADLDSFVPS DLITTIDKLG KSWDPSLLSF YAALASFPAF 180
YDLQEADLDK EFRLPTTTFI GGPENTLSLR EIIRRLESTY CQHIGLEFMF INDVEQCQWI 240
RQKFETPGVM QFSVEEKRTL LARLVRSMRF EDFLARKWSS EKRFGLEGCE VMIPALKTII 300
DKSSEMGIEN VILGMPHRGR LNVLANVIRK DLEQIFCQFD PKLEAADEGS GDVKYHLGMY 360
HERINRVTNR NITLSLVANP SHLEAVDPVV QGKTKAEQFY RGDAQGRKVM SILVHGDAAF 420
AGQGVVYETF HLSDLPSYTT NGTVHVVVNN QIGFTTDPRM ARSSPYPTDV ARVVNAPIFH 480
VNADDPEAVI YVCSVAAEWR NTFNKDVVVD LVCYRRRGHN EMDEPMFTQP LMYKQIHKQV 540
PVLKKYADKL IAEGTVTLQE FEEEIAKYDR ICEEAYGRSK DKKILHIKHW LDSPWPGFFN 600
VDGEPKSMTC PTTGIPEEML THIGSVASSV PLEDFKIHTG LSRILRGRAD MTKKRTVDWA 660
LAEYMAFGSL LKEGIHVRLS GQDVERGTFS HRHHVLHDQE VDRRTCVPMN HLWPDQAPYT 720
VCNSSLSEYG VLGFELGYAM ASPNALVLWE AQFGDFHNTA QCIIDQFIST GQAKWVRHNG 780
IVLLLPHGME GMGPEHSSAR PERFLQMSND DSDAYPVFTE DFEVSQLYDC NWIVVNCSTP 840
ASYFHVLRRQ ILLPFRKPLI VFTPKSLLRH PDAKSSFDQM VSGTSFQRLI PEDGPAAHSP 900
EQVQRLIFCT GKVYYDLVKE RSSQGLEQQV AITRLEQISP FPFDLIMREA EKYSGAELVW 960
CQEEHKNMGY YDYISPRFMT LLGHSRPIWY VGRDPAAAPA TGNKNAHLVS LRRFLDTAFN 1020
LKAFEGKTF 1029 
Gene Ontology
 GO:0004591; F:oxoglutarate dehydrogenase (succinyl-transferring) activity; IEA:InterPro.
 GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
 GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro. 
Interpro
 IPR011603; 2oxoglutarate_DH_E1.
 IPR001017; DH_E1.
 IPR005475; Transketolase-like_Pyr-bd. 
Pfam
 PF00676; E1_dh
 PF02779; Transket_pyr 
SMART
 SM00861; Transket_pyr 
PROSITE
  
PRINTS