CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011050
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Translation initiation factor RLI1 
Protein Synonyms/Alias
 ATP-binding cassette sub-family E member RLI1; RNase L inhibitor 
Gene Name
 RLI1 
Gene Synonyms/Alias
 YDR091C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
121IGKSTALKILAGKQKacetylation[1]
192QKVGELLKLRMEKSPacetylation[1]
216LQLENVLKRDIEKLSacetylation[1]
221VLKRDIEKLSGGELQacetylation[1]
221VLKRDIEKLSGGELQubiquitination[2]
403KLLAGALKPDEGQDIacetylation[1]
508EQRIICSKVIRRFILubiquitination[2]
566TGCNRFLKNLNVTFRacetylation[1]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Component of the multifactor complex (MFC) involved in translation initiation. Required for the binding of MFC to the 40S ribosome. Required for the processing and nuclear export of the 60S and 40S ribosomal subunits. 
Sequence Annotation
 DOMAIN 7 39 4Fe-4S ferredoxin-type 1.
 DOMAIN 46 75 4Fe-4S ferredoxin-type 2.
 DOMAIN 70 320 ABC transporter 1.
 DOMAIN 345 568 ABC transporter 2.
 NP_BIND 110 117 ATP (Potential).
 NP_BIND 385 392 ATP (Potential).
 MOD_RES 349 349 Phosphoserine.  
Keyword
 3D-structure; ATP-binding; Complete proteome; Cytoplasm; Initiation factor; Nucleotide-binding; Nucleus; Phosphoprotein; Protein biosynthesis; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 608 AA 
Protein Sequence
MSDKNSRIAI VSADKCKPKK CRQECKRSCP VVKTGKLCIE VTPTSKIAFI SEILCIGCGI 60
CVKKCPFDAI QIINLPTNLE AHVTHRYSAN SFKLHRLPTP RPGQVLGLVG TNGIGKSTAL 120
KILAGKQKPN LGRFDDPPEW QEIIKYFRGS ELQNYFTKML EDDIKAIIKP QYVDNIPRAI 180
KGPVQKVGEL LKLRMEKSPE DVKRYIKILQ LENVLKRDIE KLSGGELQRF AIGMSCVQEA 240
DVYMFDEPSS YLDVKQRLNA AQIIRSLLAP TKYVICVEHD LSVLDYLSDF VCIIYGVPSV 300
YGVVTLPASV REGINIFLDG HIPAENLRFR TEALQFRIAD ATEDLQNDSA SRAFSYPSLK 360
KTQGDFVLNV EEGEFSDSEI LVMMGENGTG KTTLIKLLAG ALKPDEGQDI PKLNVSMKPQ 420
KIAPKFPGTV RQLFFKKIRG QFLNPQFQTD VVKPLRIDDI IDQEVQHLSG GELQRVAIVL 480
ALGIPADIYL IDEPSAYLDS EQRIICSKVI RRFILHNKKT AFIVEHDFIM ATYLADKVIV 540
FEGIPSKNAH ARAPESLLTG CNRFLKNLNV TFRRDPNSFR PRINKLDSQM DKEQKSSGNY 600
FFLDNTGI 608 
Gene Ontology
 GO:0022626; C:cytosolic ribosome; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016887; F:ATPase activity; ISS:SGD.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0005506; F:iron ion binding; IDA:SGD.
 GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
 GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
 GO:0042273; P:ribosomal large subunit biogenesis; IMP:SGD.
 GO:0000054; P:ribosomal subunit export from nucleus; IMP:SGD.
 GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
 GO:0006413; P:translational initiation; IMP:SGD.
 GO:0006415; P:translational termination; IGI:SGD. 
Interpro
 IPR001450; 4Fe4S-bd_dom.
 IPR017896; 4Fe4S_Fe-S-bd.
 IPR017900; 4Fe4S_Fe_S_CS.
 IPR003593; AAA+_ATPase.
 IPR013283; ABC_E.
 IPR003439; ABC_transporter-like.
 IPR017871; ABC_transporter_CS.
 IPR027417; P-loop_NTPase.
 IPR007209; RNaseL-inhib_metal-bd_dom. 
Pfam
 PF00005; ABC_tran
 PF00037; Fer4
 PF04068; RLI 
SMART
 SM00382; AAA 
PROSITE
 PS00198; 4FE4S_FER_1
 PS51379; 4FE4S_FER_2
 PS00211; ABC_TRANSPORTER_1
 PS50893; ABC_TRANSPORTER_2 
PRINTS
 PR01868; ABCEFAMILY.