CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024978
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Putative gag-pol protein 
Protein Synonyms/Alias
  
Gene Name
 ENSMUSG00000073624 
Gene Synonyms/Alias
 gag-pol 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
64GKYTGLSKGLEPEEKubiquitination[1]
71KGLEPEEKLRSGRNTubiquitination[1]
228PVEYVQIKEIAESVRubiquitination[1]
236EIAESVRKYGTNANFubiquitination[1]
378KDLTMLQKAYPFLLKubiquitination[1]
416GSVVSPDKIVPQKVEubiquitination[1]
421PDKIVPQKVEIRRDHubiquitination[1]
485AANQALQKVEKALQNubiquitination[1]
488QALQKVEKALQNAQLubiquitination[1]
749LGNDLADKATKVVAAubiquitination[1]
752DLADKATKVVAAALSubiquitination[1]
880WGKPRLLKTDNGPAYubiquitination[1]
891GPAYTSQKFQQFCRQubiquitination[1]
991WKNVLDNKWYGPDPIubiquitination[1]
1026VPERLTRKIQTDQGNubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
  
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1067 AA 
Protein Sequence
MALQVMFGLK FFLVLEALLF LFTCYIVLKI GLKILEEIQD SLSEVKRGER VGARRNGKYT 60
GLSKGLEPEE KLRSGRNTWG EIRRKKKKKE KKKDRLAEVS RRRSLCSEET DWEKKAAHYE 120
RKGYQPPSKV LTSHSRKKPK AAGEGQFANW PQGNRLPGAL PPYAESPPCV VRQPVVRQQC 180
AERQCAERQC ADSFIPREEQ RKIEQAFPVF KGAEGGRVHA PVEYVQIKEI AESVRKYGTN 240
ANFTLAQLDR LAGVALTPAD WQMIAKVALP SMAKYVEWRA LWQEAAQAQA RANAAALTPE 300
QRDWTFDLLT GQRAYSAEPD KRYQWKILPQ GMSNSPIMCQ LYIQEALLPV REQFPSLILL 360
LYMDDILLCH KDLTMLQKAY PFLLKTLSQW GLQIATEKVQ ISDTGQFLGS VVSPDKIVPQ 420
KVEIRRDHLH TLNDFQKLLG DINWLRPFLK IPSAELRPLF SILEGDPHIS SPRTLTLAAN 480
QALQKVEKAL QNAQLQRIED SQPFSLCVFK TAQLPTAVLW QNGPLLWIHP NVSPAKIIDW 540
YPDAIAQLAL KGLKAAITHF GQSPYLLIVP YTAAQVQTLA AASNDWAVLV TSFSGKIDNH 600
YPKHPILQFA QNQSVVFPQI TVRNPLKNGI VVYTDGSKTG IGAYVANGKV VSKQYNENSP 660
QVVECLVVLE VLKTFLKPLN IVSDSCYVVN AVNLLEVAGV IKPSSRVANI FQQIQLVLLS 720
RRSPVYITHV RAHSGLPGPM ALGNDLADKA TKVVAAALSS PVEAARNFHN NFHVTAETLR 780
SRFSLTRKEA RDIVTQCQSC CEFLPVPHVG INPRGIRPLQ VWQMDVTHVS SFGKLQYLHV 840
SIDTCSGIMF ASPLTGEKAS HVIQHCLEAW SAWGKPRLLK TDNGPAYTSQ KFQQFCRQMD 900
VTHLTGLPYN PQGQGIVERA HRTLKAYLIK QKRGTFEETV PRAPRVSVSL ALFTLNFLNI 960
DAHGHTAAER HCSEPDRPNE MVKWKNVLDN KWYGPDPILI RSRGAICVFP QNEDNPFWVP 1020
ERLTRKIQTD QGNTNVPRLG DVQGVNNKER AALGDNVDIS TPNDGDV 1067 
Gene Ontology
 GO:0004523; F:ribonuclease H activity; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:InterPro.
 GO:0003964; F:RNA-directed DNA polymerase activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0015074; P:DNA integration; IEA:InterPro.
 GO:0006278; P:RNA-dependent DNA replication; IEA:InterPro.
 GO:0016032; P:viral reproduction; IEA:InterPro. 
Interpro
 IPR000721; Gag_p24.
 IPR001037; Integrase_C_retrovir.
 IPR001584; Integrase_cat-core.
 IPR017856; Integrase_Zn-bd_dom-like_N.
 IPR003308; Integrase_Zn-bd_dom_N.
 IPR008919; Retrov_capsid_N.
 IPR012337; RNaseH-like_dom.
 IPR002156; RNaseH_domain.
 IPR000477; RVT.
 IPR010661; RVT_thumb. 
Pfam
 PF00607; Gag_p24
 PF00552; IN_DBD_C
 PF02022; Integrase_Zn
 PF00075; RNase_H
 PF00665; rve
 PF00078; RVT_1
 PF06817; RVT_thumb 
SMART
  
PROSITE
 PS50994; INTEGRASE
 PS51027; INTEGRASE_DBD
 PS50879; RNASE_H
 PS50878; RT_POL
 PS50876; ZF_INTEGRASE 
PRINTS