UniProt Accession

 LKHA4_HUMAN; P09960; B4DNQ9; F8VV40; Q6IAT6; Q9UCT7 

Genbank Protein ID

 J03459; J02959; U27293; U27275; U27276; U27277; U27278; U27279; U27280; U27281; U27282; U27283; U27284; U27285; U27286; U27287; U27288; U27289; U27290; U27291; U27292; AK298017; CR457068; BX647158; AC007298; CH471054; BC032528; U43410; U43411 

Genbank Nucleotide ID

 AAA36176.1; AAA36177.1; AAA89077.1; AAA89077.1; AAA89077.1; AAA89077.1; AAA89077.1; AAA89077.1; AAA89077.1; AAA89077.1; AAA89077.1; AAA89077.1; AAA89077.1; AAA89077.1; AAA89077.1; AAA89077.1; AAA89077.1; AAA89077.1; AAA89077.1; AAA89077.1; AAA89077.1; BAG60321.1; CAG33349.1; EAW97559.1; AAH32528.1 

Protein Name

 Leukotriene A-4 hydrolase 

Protein Synonyms/Alias

 LTA-4 hydrolase; Leukotriene A(4) hydrolase 

Gene Name

 LTA4H 

Gene Synonyms/Alias

 LTA4 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
73	VINGQEVKYALGERQ	ubiquitination	[1]
230	SEKEQVEKSAYEFSE	ubiquitination	[1]
355	GELQNSVKTFGETHP	ubiquitination	[1]
418	YVEKFSYKSITTDDW	ubiquitination	[1]
480	SQRWITAKEDDLNSF	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity. 

Sequence Annotation

 REGION 135 137 Substrate binding.
 REGION 267 272 Substrate binding.
 REGION 564 566 Substrate binding.
 ACT_SITE 297 297 Proton acceptor (Probable).
 ACT_SITE 384 384 Proton donor (Probable).
 METAL 296 296 Zinc; catalytic.
 METAL 300 300 Zinc; catalytic.
 METAL 319 319 Zinc; catalytic.
 MOD_RES 73 73 N6-acetyllysine.
 MOD_RES 337 337 N6-acetyllysine.
 MOD_RES 414 414 N6-acetyllysine.
 MOD_RES 416 416 Phosphoserine.
 MOD_RES 573 573 N6-acetyllysine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Hydrolase; Leukotriene biosynthesis; Metal-binding; Metalloprotease; Phosphoprotein; Polymorphism; Protease; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 611 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0004177; F:aminopeptidase activity; IDA:UniProtKB.
 GO:0004301; F:epoxide hydrolase activity; IDA:UniProtKB.
 GO:0004463; F:leukotriene-A4 hydrolase activity; IDA:UniProtKB.
 GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IDA:UniProtKB.
 GO:0019369; P:arachidonic acid metabolic process; TAS:Reactome.
 GO:0006954; P:inflammatory response; NAS:ProtInc.
 GO:0019370; P:leukotriene biosynthetic process; IDA:UniProtKB.
 GO:0043171; P:peptide catabolic process; IDA:UniProtKB.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 

Interpro

 IPR016024; ARM-type_fold.
 IPR012777; Leukotriene_A4_hydrolase.
 IPR001930; Peptidase_M1.
 IPR015211; Peptidase_M1_C.
 IPR014782; Peptidase_M1_N. 

Pfam

 PF09127; Leuk-A4-hydro_C
 PF01433; Peptidase_M1 

SMART

  

PROSITE

 PS00142; ZINC_PROTEASE 

PRINTS

 PR00756; ALADIPTASE.