UniProt Accession

 LEPR_HUMAN; P48357; Q13592; Q13593; Q13594; Q92919; Q92920; Q92921 

Genbank Protein ID

 U43168; U66495; U66496; U66497; U52912; U52913; U52914; U59263; U59248; U59249; U59250; U59252; U59253; U59254; U59255; U59256; U59257; U59258; U59259; U59260; U59261; U59262; U50748 

Genbank Nucleotide ID

 AAA93015.1; AAB07495.1; AAB07496.1; AAB07497.1; AAC50509.1; AAC50510.1; AAC50511.1; AAB09673.1; AAB09673.1; AAB09673.1; AAB09673.1; AAB09673.1; AAB09673.1; AAB09673.1; AAB09673.1; AAB09673.1; AAB09673.1; AAB09673.1; AAB09673.1; AAB09673.1; AAB09673.1; AAB09673.1; AAC23650.1 

Protein Name

 Leptin receptor 

Protein Synonyms/Alias

 LEP-R; HuB219; OB receptor; OB-R; CD295 

Gene Name

 LEPR 

Gene Synonyms/Alias

 DB; OBR 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
658	GDTMKKEKNVTLLWK	ubiquitination	[1]
879	WEDVPNPKNCSWAQG	ubiquitination	[2]
891	AQGLNFQKPETFEHL	ubiquitination	[2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Computational identification of ubiquitylation sites from protein sequences.
 Tung CW, Ho SY.
 BMC Bioinformatics. 2008 Jul 15;9:310. [PMID: 18625080] 

Functional Description

 Receptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway (By similarity). 

Sequence Annotation

 DOMAIN 237 330 Fibronectin type-III 1.
 DOMAIN 331 429 Ig-like.
 DOMAIN 537 631 Fibronectin type-III 2.
 DOMAIN 639 732 Fibronectin type-III 3.
 DOMAIN 734 829 Fibronectin type-III 4.
 REGION 467 484 Leptin-binding (Probable).
 REGION 893 898 Required for JAK2 activation (By
 MOTIF 622 626 WSXWS motif.
 MOTIF 871 879 Box 1 motif.
 MOD_RES 986 986 Phosphotyrosine; by JAK2 (By similarity).
 MOD_RES 1079 1079 Phosphotyrosine (By similarity).
 MOD_RES 1141 1141 Phosphotyrosine; by JAK2 (By similarity).
 CARBOHYD 23 23 N-linked (GlcNAc...).
 CARBOHYD 41 41 N-linked (GlcNAc...).
 CARBOHYD 56 56 N-linked (GlcNAc...).
 CARBOHYD 73 73 N-linked (GlcNAc...).
 CARBOHYD 81 81 N-linked (GlcNAc...).
 CARBOHYD 98 98 N-linked (GlcNAc...).
 CARBOHYD 187 187 N-linked (GlcNAc...).
 CARBOHYD 206 206 N-linked (GlcNAc...).
 CARBOHYD 276 276 N-linked (GlcNAc...).
 CARBOHYD 347 347 N-linked (GlcNAc...).
 CARBOHYD 397 397 N-linked (GlcNAc...).
 CARBOHYD 516 516 N-linked (GlcNAc...).
 CARBOHYD 624 624 N-linked (GlcNAc...).
 CARBOHYD 659 659 N-linked (GlcNAc...).
 CARBOHYD 688 688 N-linked (GlcNAc...).
 CARBOHYD 697 697 N-linked (GlcNAc...).
 CARBOHYD 728 728 N-linked (GlcNAc...).
 CARBOHYD 750 750 N-linked (GlcNAc...).
 DISULFID 37 90
 DISULFID 89 99
 DISULFID 131 142
 DISULFID 186 196
 DISULFID 188 193
 DISULFID 352 412
 DISULFID 413 418
 DISULFID 436 447
 DISULFID 473 528
 DISULFID 488 498  

Keyword

 3D-structure; Alternative splicing; Cell membrane; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Obesity; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Repeat; Secreted; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 1165 AA 

Protein Sequence

Gene Ontology

 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0004896; F:cytokine receptor activity; IEA:InterPro.
 GO:0004888; F:transmembrane signaling receptor activity; TAS:ProtInc.
 GO:0008203; P:cholesterol metabolic process; IEA:Compara.
 GO:0019221; P:cytokine-mediated signaling pathway; IEA:GOC.
 GO:0006112; P:energy reserve metabolic process; TAS:ProtInc.
 GO:0007275; P:multicellular organismal development; TAS:ProtInc.
 GO:0051346; P:negative regulation of hydrolase activity; IEA:Compara. 

Interpro

 IPR003961; Fibronectin_type3.
 IPR003529; Hematopoietin_rcpt_Gp130_CS.
 IPR003531; Hempt_rcpt_S_F1_CS.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR010457; IgC2-like_lig-bd.
 IPR015752; Lep_receptor. 

Pfam

 PF06328; Lep_receptor_Ig 

SMART

 SM00060; FN3 

PROSITE

 PS50853; FN3
 PS01353; HEMATOPO_REC_L_F2
 PS50835; IG_LIKE 

PRINTS