| Tag | Content |
|---|
| CPLM ID | CPLM-017801 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Acylamino-acid-releasing enzyme |
Protein Synonyms/Alias | AARE; Acyl-peptide hydrolase; APH; Acylaminoacyl-peptidase |
Gene Name | Apeh |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 126 | QFLEVWEKNRKLKSF | ubiquitination | [1] | | 131 | WEKNRKLKSFNLSAL | ubiquitination | [1] | | 180 | AESFFQTKALDVSAS | ubiquitination | [1] | | 434 | PNLPPSLKVGFLPPA | ubiquitination | [1] | | 658 | MLDKSPIKYIPQVKT | ubiquitination | [1] | | 664 | IKYIPQVKTPVLLML | ubiquitination | [1] | | 681 | EDRRVPFKQGLEYYH | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N- acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser (By similarity). |
Sequence Annotation | ACT_SITE 587 587 Charge relay system (By similarity).
ACT_SITE 675 675 Charge relay system (By similarity).
ACT_SITE 707 707 Charge relay system (By similarity).
MOD_RES 1 1 N-acetylmethionine (By similarity).
MOD_RES 185 185 Phosphoserine (By similarity).
MOD_RES 187 187 Phosphoserine (By similarity). |
Keyword | Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Hydrolase; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 732 AA |
Protein Sequence | MERQVLLSEP QEAAALYRGL SRQPSLSAAC LGPEVTTQYG GLYRTVHTEW TQRDLDRMEN 60
IRFCRQYLVF HDGDSVVFAG PAGNSVETRG ELLSRESPSG TMKAVLRKAG GAVSGEEKQF 120
LEVWEKNRKL KSFNLSALEK HGPVYEDDCF GCLSWSHSET HLLYVAEKKR PKAESFFQTK 180
ALDVSASDEE MARPKKPDQA IKGDQFVFYE DWGETMVSKS IPVLCVLDIE SGNISVLEGV 240
PENVSPGQAF WAPGDTGVVF VGWWHEPFRL GIRYCTNRRS ALYYVDLSGG KCELLSDESL 300
AVCSPRLSPD QCRVVYLQYP SLAPHHQCSQ LFLYDWYTKV TSLVVDIVPR QLGESFSGIY 360
CSLLPLGCWS ADSQRVVFDS VQRSRQDLFA VDTQTGSVTS LTAGGSAGSW KLLTIDRDLM 420
VAQFSTPNLP PSLKVGFLPP AGKEQSVSWV SLEEAEPIPD IHWGIRVLHP PPDQENVQYA 480
DLDFEAILLQ PSNSPDKSQV PMVVMPHGGP HSSFVTAWML FPAMLCKMGF AVLLVNYRGS 540
TGFGQDSILS LPGNVGHQDV KDVQFAVQQV LQEEHFDARR VALMGGSHGG FLSCHLIGQY 600
PETYSACIAR NPVINIVSMM GTTDIPDWCM VETGFPYSND YLPDLNVLEE MLDKSPIKYI 660
PQVKTPVLLM LGQEDRRVPF KQGLEYYHAL KARNVPVRLL LYPKSTHALS EVEVESDSFM 720
NTVLWLHTHL GS 732 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |