Tag | Content |
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CPLM ID | CPLM-019921 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Elongator complex protein 5 |
Protein Synonyms/Alias | Dermal papilla-derived protein 6 homolog; Retinoic acid-induced protein 12 |
Gene Name | Elp5 |
Gene Synonyms/Alias | Derp6; Rai12 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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263 | PFQFSSEKQKALLHP | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. May be involved in TP53-mediated transcriptional regulation. Involved in cell migration. |
Sequence Annotation | |
Keyword | Complete proteome; Cytoplasm; Nucleus; Reference proteome; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 300 AA |
Protein Sequence | MLDSLLAIGG LVLLRDSVEW EGRSLLKALI KKSALRGEQV HVLGCEVSEE EFREGFDSDV 60 NSRLVYHDLF RDPLNWSKPG EAVPEGPLKA LRSMCKRTDH GSVTIALDSL SWLLCHIPCV 120 TLCQALHALS QQNGDPGDNS LVEQVRVLGL LHEELHGPGS MGALNTLAHT EVTLSGKVDQ 180 TSASILCRRP QQRATYQTWW FSVLPDFSLT LHEGLPLRSE LHPDHHTTQV DPTAHLTFNL 240 HLSKKEREAR DSLTLPFQFS SEKQKALLHP VPSRTTGHIF YEPDAFDDVD PEDPDDDLDI 300 |
Gene Ontology | GO:0005737; C:cytoplasm; ISS:UniProtKB. GO:0033588; C:Elongator holoenzyme complex; ISS:UniProtKB. GO:0005634; C:nucleus; ISS:UniProtKB. GO:0030335; P:positive regulation of cell migration; IMP:UniProtKB. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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PRINTS | |