UniProt Accession

 NH2L1_MOUSE; Q9D0T1; O08754; Q3UY64 

Genbank Protein ID

 U95114; AK004489; AK134943; AK145608; AK168930; AK169103; BC026755; BC054450; BC083315 

Genbank Nucleotide ID

 AAC53177.1; BAB23329.1; BAE22349.1; BAE26537.1; BAE40743.1; BAE40885.1; AAH26755.1; AAH54450.1; AAH83315.1 

Protein Name

 NHP2-like protein 1 

Protein Synonyms/Alias

 Fertilization antigen 1; FA-1; High mobility group-like nuclear protein 2 homolog 1; Sperm-specific antigen 1; U4/U6.U5 tri-snRNP 15.5 kDa protein; NHP2-like protein 1, N-terminally processed 

Gene Name

 Nhp2l1 

Gene Synonyms/Alias

 Ssfa1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
21	ADAHLTKKLLDLVQQ	ubiquitination	[1]
33	VQQSCNYKQLRKGAN	ubiquitination	[1]
113	IKEGSQLKQQIQSIQ	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Binds to the 5'-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding (By similarity). 

Sequence Annotation

 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 2 2 N-acetylthreonine; in NHP2-like protein  

Keyword

 Acetylation; Complete proteome; mRNA processing; mRNA splicing; Nucleus; Reference proteome; Ribonucleoprotein; RNA-binding; Spliceosome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 128 AA 

Protein Sequence

Gene Ontology

 GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
 GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0042254; P:ribosome biogenesis; IEA:InterPro.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. 

Interpro

 IPR002415; H/ACA_rnp_Nhp2_euk.
 IPR004038; Ribosomal_L7Ae/L30e/S12e/Gad45.
 IPR018492; Ribosomal_L7Ae/L8/Nhp2.
 IPR004037; Ribosomal_L7Ae_CS. 

Pfam

 PF01248; Ribosomal_L7Ae 

SMART

  

PROSITE

 PS01082; RIBOSOMAL_L7AE 

PRINTS

 PR00881; L7ARS6FAMILY.
 PR00883; NUCLEARHMG.