UniProt Accession

 ACHA9_HUMAN; Q9UGM1; Q14CY7; Q4W5A2; Q9NYV2 

Genbank Protein ID

 AJ243342; AY123244; AC118275; BC113549; BC113575; AF227732 

Genbank Nucleotide ID

 CAB65091.1; AAM74523.1; AAY40986.1; AAI13550.1; AAI13576.1; AAF61920.1 

Protein Name

 Neuronal acetylcholine receptor subunit alpha-9 

Protein Synonyms/Alias

 Nicotinic acetylcholine receptor subunit alpha-9; NACHR alpha-9 

Gene Name

 CHRNA9 

Gene Synonyms/Alias

 NACHRA9 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
122	PDIVLYNKADDESSE	ubiquitination	[1]
376	HLTKVYSKLPESNLK	ubiquitination	[2]
409	NDLGCQGKNPQEAES	ubiquitination	[1, 2]
422	ESYCAQYKVLTRNIE	ubiquitination	[2, 3]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion. 

Sequence Annotation

 CARBOHYD 57 57 N-linked (GlcNAc...) (Potential).
 CARBOHYD 170 170 N-linked (GlcNAc...) (Potential).
 DISULFID 155 169 By similarity.
 DISULFID 219 220 Associated with receptor activation (By  

Keyword

 Calcium; Calcium channel; Calcium transport; Cell junction; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Ion channel; Ion transport; Ligand-gated ion channel; Membrane; Polymorphism; Postsynaptic cell membrane; Receptor; Reference proteome; Signal; Synapse; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 479 AA 

Protein Sequence

Gene Ontology

 GO:0005892; C:acetylcholine-gated channel complex; IEA:Compara.
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
 GO:0004889; F:acetylcholine-activated cation-selective channel activity; IEA:Compara.
 GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW.
 GO:0050910; P:detection of mechanical stimulus involved in sensory perception of sound; IEA:Compara.
 GO:0007204; P:elevation of cytosolic calcium ion concentration; IGI:MGI.
 GO:0042472; P:inner ear morphogenesis; IEA:Compara.
 GO:0007268; P:synaptic transmission; TAS:Reactome. 

Interpro

 IPR027361; Acetylcholine_rcpt_TM.
 IPR006202; Neur_chan_lig-bd.
 IPR006201; Neur_channel.
 IPR006029; Neurotrans-gated_channel_TM.
 IPR018000; Neurotransmitter_ion_chnl_CS.
 IPR002394; Nicotinic_acetylcholine_rcpt. 

Pfam

 PF02931; Neur_chan_LBD
 PF02932; Neur_chan_memb 

SMART

  

PROSITE

 PS00236; NEUROTR_ION_CHANNEL 

PRINTS

 PR00254; NICOTINICR.
 PR00252; NRIONCHANNEL.