CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013889
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Phosphoenolpyruvate carboxykinase [ATP] 
Protein Synonyms/Alias
 PEP carboxykinase; PEPCK; Phosphoenolpyruvate carboxylase 
Gene Name
 pckA 
Gene Synonyms/Alias
 tthHB8IM; TTHA0278 
Created Date
 July 27, 2013 
Organism
 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) 
NCBI Taxa ID
 300852 
Lysine Modification
Position
Peptide
Type
References
413YARMLGEKIRKHAPRacetylation[1]
512LFQENFQKYASGVAKacetylation[1]
Reference
 [1] Acetylome with structural mapping reveals the significance of lysine acetylation in Thermus thermophilus.
 Okanishi H, Kim K, Masui R, Kuramitsu S.
 J Proteome Res. 2013 Aug 1;. [PMID: 23901841] 
Functional Description
  
Sequence Annotation
 NP_BIND 232 239 ATP.
 METAL 130 130 Calcium; via carbonyl oxygen.
 METAL 131 131 Calcium; via carbonyl oxygen.
 METAL 133 133 Calcium; via carbonyl oxygen.
 METAL 267 267 Calcium; via carbonyl oxygen.
 BINDING 439 439 ATP; via carbonyl oxygen.
 BINDING 444 444 ATP.  
Keyword
 3D-structure; ATP-binding; Calcium; Complete proteome; Cytoplasm; Decarboxylase; Gluconeogenesis; Lyase; Metal-binding; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 529 AA 
Protein Sequence
MQRLEALGIH PKKRVFWNTV SPVLVEHTLL RGEGLLAHHG PLVVDTTPYT GRSPKDKFVV 60
REPEVEGEIW WGEVNQPFAP EAFEALYQRV VQYLSERDLY VQDLYAGADR RYRLAVRVVT 120
ESPWHALFAR NMFILPRRFG NDDEVEAFVP GFTVVHAPYF QAVPERDGTR SEVFVGISFQ 180
RRLVLIVGTK YAGEIKKSIF TVMNYLMPKR GVFPMHASAN VGKEGDVAVF FGLSGTGKTT 240
LSTDPERPLI GDDEHGWSED GVFNFEGGCY AKVIRLSPEH EPLIYKASNQ FEAILENVVV 300
NPESRRVQWD DDSKTENTRS SYPIAHLENV VESGVAGHPR AIFFLSADAY GVLPPIARLS 360
PEEAMYYFLS GYTARVAGTE RGVTEPRATF SACFGAPFLP MHPGVYARML GEKIRKHAPR 420
VYLVNTGWTG GPYGVGYRFP LPVTRALLKA ALSGALENVP YRRDPVFGFE VPLEAPGVPQ 480
ELLNPRETWA DKEAYDQQAR KLARLFQENF QKYASGVAKE VAEAGPRTE 529 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:HAMAP.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004612; F:phosphoenolpyruvate carboxykinase (ATP) activity; IEA:HAMAP.
 GO:0006094; P:gluconeogenesis; IEA:HAMAP. 
Interpro
 IPR001272; PEP_carboxykinase_ATP.
 IPR013035; PEP_carboxykinase_C.
 IPR008210; PEP_carboxykinase_N.
 IPR015994; PEPCK_ATP_CS. 
Pfam
 PF01293; PEPCK_ATP 
SMART
  
PROSITE
 PS00532; PEPCK_ATP 
PRINTS