| Tag | Content |
|---|
| CPLM ID | CPLM-022375 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Myotubularin-related protein 4 |
Protein Synonyms/Alias | FYVE domain-containing dual specificity protein phosphatase 2; FYVE-DSP2; Zinc finger FYVE domain-containing protein 11 |
Gene Name | MTMR4 |
Gene Synonyms/Alias | KIAA0647; ZFYVE11 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 184 | SHINSNYKLCPSYPQ | ubiquitination | [1] | | 202 | VPVWITDKELENVAS | ubiquitination | [1] | | 257 | YLVTSIAKACALDPG | ubiquitination | [1] | | 882 | LENPRFGKMPLELVR | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate. Phosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3). |
Sequence Annotation | DOMAIN 153 570 Myotubularin phosphatase.
ZN_FING 1114 1174 FYVE-type.
REGION 320 323 Substrate binding (By similarity).
REGION 345 346 Substrate binding (By similarity).
REGION 407 413 Substrate binding (By similarity).
ACT_SITE 407 407 Phosphocysteine intermediate (By
BINDING 453 453 Substrate (By similarity). |
Keyword | Coiled coil; Complete proteome; Cytoplasm; Hydrolase; Membrane; Metal-binding; Polymorphism; Protein phosphatase; Reference proteome; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1195 AA |
Protein Sequence | MGEEGPPSLE YIQAKDLFPP KELVKEEENL QVPFTVLQGE GVEFLGRAAD ALIAISNYRL 60
HIKFKDSVIN VPLRMIDSVE SRDMFQLHIS CKDSKVVRCH FSTFKQCQEW LSRLSRATAR 120
PAKPEDLFAF AYHAWCLGLT EEDQHTHLCQ PGEHIRCRQE AELARMGFDL QNVWRVSHIN 180
SNYKLCPSYP QKLLVPVWIT DKELENVASF RSWKRIPVVV YRHLRNGAAI ARCSQPEISW 240
WGWRNADDEY LVTSIAKACA LDPGTRATGG SLSTGNNDTS EACDADFDSS LTACSGVEST 300
AAPQKLLILD ARSYTAAVAN RAKGGGCECE EYYPNCEVVF MGMANIHAIR NSFQYLRAVC 360
SQMPDPSNWL SALESTKWLQ HLSVMLKAAV LVANTVDREG RPVLVHCSDG WDRTPQIVAL 420
AKILLDPYYR TLEGFQVLVE SDWLDFGHKF GDRCGHQENV EDQNEQCPVF LQWLDSVHQL 480
LKQFPCLFEF NEAFLVKLVQ HTYSCLYGTF LANNPCEREK RNIYKRTCSV WALLRAGNKN 540
FHNFLYTPSS DMVLHPVCHV RALHLWTAVY LPASSPCTLG EENMDLYLSP VAQSQEFSGR 600
SLDRLPKTRS MDDLLSACDT SSPLTRTSSD PNLNNHCQEV RVGLEPWHSN PEGSETSFVD 660
SGVGGPQQTV GEVGLPPPLP SSQKDYLSNK PFKSHKSCSP SYKLLNTAVP REMKSNTSDP 720
EIKVLEETKG PAPDPSAQDE LGRTLDGIGE PPEHCPETEA VSALSKVISN KCDGVCNFPE 780
SSQNSPTGTP QQAQPDSMLG VPSKCVLDHS LSTVCNPPSA ACQTPLDPST DFLNQDPSGS 840
VASISHQEQL SSVPDLTHGE EDIGKRGNNR NGQLLENPRF GKMPLELVRK PISQSQISEF 900
SFLGSNWDSF QGMVTSFPSG EATPRRLLSY GCCSKRPNSK QMRATGPCFG GQWAQREGVK 960
SPVCSSHSNG HCTGPGGKNQ MWLSSHPKQV SSTKPVPLNC PSPVPPLYLD DDGLPFPTDV 1020
IQHRLRQIEA GYKQEVEQLR RQVRELQMRL DIRHCCAPPA EPPMDYEDDF TCLKESDGSD 1080
TEDFGSDHSE DCLSEASWEP VDKKETEVTR WVPDHMASHC YNCDCEFWLA KRRHHCRNCG 1140
NVFCAGCCHL KLPIPDQQLY DPVLVCNSCY EHIQVSRARE LMSQQLKKPI ATASS 1195 |
Gene Ontology | GO:0005829; C:cytosol; TAS:Reactome. GO:0031901; C:early endosome membrane; TAS:Reactome. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0004722; F:protein serine/threonine phosphatase activity; TAS:Reactome. GO:0004725; F:protein tyrosine phosphatase activity; TAS:ProtInc. GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; TAS:Reactome. GO:0006661; P:phosphatidylinositol biosynthetic process; TAS:Reactome. GO:0044281; P:small molecule metabolic process; TAS:Reactome. GO:0007179; P:transforming growth factor beta receptor signaling pathway; TAS:Reactome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |