| Tag | Content |
|---|
| CPLM ID | CPLM-012329 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Helicase-like transcription factor |
Protein Synonyms/Alias | DNA-binding protein/plasminogen activator inhibitor 1 regulator; HIP116; RING finger protein 80; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3; Sucrose nonfermenting protein 2-like 3 |
Gene Name | HLTF |
Gene Synonyms/Alias | HIP116A; RNF80; SMARCA3; SNF2L3; ZBU1 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 306 | SETKGRAKAGSSKVI | ubiquitination | [1] | | 311 | RAKAGSSKVIEDVAF | ubiquitination | [1] | | 560 | RKIYQSVKNEGRATI | ubiquitination | [1] | | 830 | RCHRLGQKQEVIITK | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA. |
Sequence Annotation | DOMAIN 435 606 Helicase ATP-binding.
DOMAIN 837 996 Helicase C-terminal.
DNA_BIND 38 287
NP_BIND 294 301 ATP (By similarity).
ZN_FING 760 801 RING-type.
REGION 925 1009 Interaction with SP1 and SP3.
MOTIF 557 560 DEGH box.
MOD_RES 195 195 Phosphotyrosine; by JAK2.
MOD_RES 397 397 Phosphoserine.
MOD_RES 398 398 Phosphoserine.
MOD_RES 400 400 Phosphoserine.
MOD_RES 635 635 Phosphoserine (By similarity).
MOD_RES 736 736 Phosphothreonine. |
Keyword | 3D-structure; Activator; Alternative initiation; ATP-binding; Chromatin regulator; Complete proteome; Cytoplasm; DNA-binding; Helicase; Hydrolase; Ligase; Metal-binding; Multifunctional enzyme; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transcription; Ubl conjugation pathway; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1009 AA |
Protein Sequence | MDNKLAQIEG VVPFGANNAF TMPLHMTFWG KEENRKAVSD QLKKHGFKLG PAPKTLGFNL 60
ESGWGSGRAG PSYSMPVHAA VQMTTEQLKT EFDKLFEDLK EDDKTHEMEP AEAIETPLLP 120
HQKQALAWMV SRENSKELPP FWEQRNDLYY NTITNFSEKD RPENVHGGIL ADDMGLGKTL 180
TAIAVILTNF HDGRPLPIER VKKNLLKKEY NVNDDSMKLG GNNTSEKADG LSKDASRCSE 240
QPSISDIKEK SKFRMSELSS SRPKRRKTAV QYIESSDSEE IETSELPQKM KGKLKNVQSE 300
TKGRAKAGSS KVIEDVAFAC ALTSSVPTTK KKMLKKGACA VEGSKKTDVE ERPRTTLIIC 360
PLSVLSNWID QFGQHIKSDV HLNFYVYYGP DRIREPALLS KQDIVLTTYN ILTHDYGTKG 420
DSPLHSIRWL RVILDEGHAI RNPNAQQTKA VLDLESERRW VLTGTPIQNS LKDLWSLLSF 480
LKLKPFIDRE WWHRTIQRPV TMGDEGGLRR LQSLIKNITL RRTKTSKIKG KPVLELPERK 540
VFIQHITLSD EERKIYQSVK NEGRATIGRY FNEGTVLAHY ADVLGLLLRL RQICCHTYLL 600
TNAVSSNGPS GNDTPEELRK KLIRKMKLIL SSGSDEECAI CLDSLTVPVI THCAHVFCKP 660
CICQVIQNEQ PHAKCPLCRN DIHEDNLLEC PPEELARDSE KKSDMEWTSS SKINALMHAL 720
TDLRKKNPNI KSLVVSQFTT FLSLIEIPLK ASGFVFTRLD GSMAQKKRVE SIQCFQNTEA 780
GSPTIMLLSL KAGGVGLNLS AASRVFLMDP AWNPAAEDQC FDRCHRLGQK QEVIITKFIV 840
KDSVEENMLK IQNKKRELAA GAFGTKKPNA DEMKQAKINE IRTLIDL 887 |
Gene Ontology | GO:0005634; C:nucleus; IDA:HPA. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0016887; F:ATPase activity; IEA:Compara. GO:0003677; F:DNA binding; TAS:ProtInc. GO:0004386; F:helicase activity; IEA:UniProtKB-KW. GO:0016874; F:ligase activity; IEA:UniProtKB-KW. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0016568; P:chromatin modification; IEA:UniProtKB-KW. GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway. GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IEA:Compara. GO:0006355; P:regulation of transcription, DNA-dependent; TAS:ProtInc. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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