UniProt Accession

 SRSF7_HUMAN; Q16629; B4DLU6; G5E9M3; Q564D3 

Genbank Protein ID

 L22253; L41887; AB445102; AY166860; BT006745; AY513287; AK297161; AC074366; CH471053; CH471053; BC000997; BC017369; BC017908; BC022328 

Genbank Nucleotide ID

 AAA35495.1; AAA88098.1; BAI99737.1; AAN87842.1; AAP35391.1; AAT08040.1; BAG59658.1; AAX93102.1; EAX00365.1; EAX00366.1; AAH00997.1; AAH17369.1; AAH17908.1; AAH22328.1 

Protein Name

 Serine/arginine-rich splicing factor 7 

Protein Synonyms/Alias

 Splicing factor 9G8; Splicing factor, arginine/serine-rich 7 

Gene Name

 SRSF7 

Gene Synonyms/Alias

 SFRS7 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
24	NLGTGAGKGELERAF	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. 

Sequence Annotation

 DOMAIN 11 84 RRM.
 REPEAT 153 160 1.
 REPEAT 161 168 2.
 REPEAT 169 176 3.
 REPEAT 177 184 4.
 REPEAT 211 218 5; approximate.
 REPEAT 219 226 6; approximate.
 ZN_FING 104 120 CCHC-type.
 REGION 153 226 6 X 8 AA repeats of R-R-S-R-S-X-S-X.
 MOD_RES 24 24 N6-acetyllysine.
 MOD_RES 163 163 Phosphoserine (By similarity).
 MOD_RES 165 165 Phosphoserine (By similarity).
 MOD_RES 167 167 Phosphoserine (By similarity).
 MOD_RES 179 179 Phosphoserine (By similarity).
 MOD_RES 181 181 Phosphoserine (By similarity).
 MOD_RES 183 183 Phosphoserine (By similarity).
 MOD_RES 187 187 Phosphoserine (By similarity).
 MOD_RES 192 192 Phosphoserine.
 MOD_RES 194 194 Phosphoserine.
 MOD_RES 196 196 Phosphoserine.
 MOD_RES 223 223 Phosphoserine (By similarity).
 MOD_RES 225 225 Phosphoserine (By similarity).
 MOD_RES 227 227 Phosphoserine (By similarity).
 MOD_RES 231 231 Phosphoserine.
 MOD_RES 233 233 Phosphoserine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Metal-binding; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; RNA-binding; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 238 AA 

Protein Sequence

Gene Ontology

 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0031124; P:mRNA 3'-end processing; TAS:Reactome.
 GO:0006406; P:mRNA export from nucleus; TAS:Reactome.
 GO:0000398; P:mRNA splicing, via spliceosome; TAS:Reactome.
 GO:0048025; P:negative regulation of mRNA splicing, via spliceosome; IDA:UniProtKB.
 GO:0006369; P:termination of RNA polymerase II transcription; TAS:Reactome. 

Interpro

 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom.
 IPR001878; Znf_CCHC. 

Pfam

 PF00076; RRM_1 

SMART

 SM00360; RRM
 SM00343; ZnF_C2HC 

PROSITE

 PS50102; RRM
 PS50158; ZF_CCHC 

PRINTS