CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021874
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ATP-sensitive inward rectifier potassium channel 10 
Protein Synonyms/Alias
 Inward rectifier K(+) channel Kir4.1; Potassium channel, inwardly rectifying subfamily J member 10 
Gene Name
 Kcnj10 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
6**MTSVAKVYYSQTTubiquitination[1]
224LLQTHQTKEGENIRLubiquitination[1]
335SLFDQVVKVASPSGLubiquitination[1]
354VRYGDPEKLKLEESLubiquitination[1]
356YGDPEKLKLEESLREubiquitination[1]
367SLREQAEKEGSALSVubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity). 
Sequence Annotation
 NP_BIND 210 217 ATP (Potential).
 MOTIF 128 133 Selectivity filter (By similarity).  
Keyword
 ATP-binding; Complete proteome; Ion channel; Ion transport; Membrane; Nucleotide-binding; Potassium; Potassium transport; Reference proteome; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 379 AA 
Protein Sequence
MTSVAKVYYS QTTQTESRPL VAPGIRRRRV LTKDGRSNVR MEHIADKRFL YLKDLWTTFI 60
DMQWRYKLLL FSATFAGTWF LFGVVWYLVA VAHGDLLELG PPANHTPCVV QVHTLTGAFL 120
FSLESQTTIG YGFRYISEEC PLAIVLLIAQ LVLTTILEIF ITGTFLAKIA RPKKRAETIR 180
FSQHAVVASH NGKPCLMIRV ANMRKSLLIG CQVTGKLLQT HQTKEGENIR LNQVNVTFQV 240
DTASDSPFLI LPLTFYHVVD ETSPLKDLPL RSGEGDFELV LILSGTVEST SATCQVRTSY 300
LPEEILWGYE FTPAISLSAS GKYIADFSLF DQVVKVASPS GLRDSTVRYG DPEKLKLEES 360
LREQAEKEGS ALSVRISNV 379 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IEA:Compara.
 GO:0016323; C:basolateral plasma membrane; IDA:MGI.
 GO:0016010; C:dystrophin-associated glycoprotein complex; IEA:Compara.
 GO:0005887; C:integral to plasma membrane; IC:MGI.
 GO:0005902; C:microvillus; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0005242; F:inward rectifier potassium channel activity; IMP:MGI.
 GO:0007628; P:adult walking behavior; IMP:MGI.
 GO:0022010; P:central nervous system myelination; IMP:MGI.
 GO:0006954; P:inflammatory response; IEA:Compara.
 GO:0051935; P:L-glutamate uptake involved in synaptic transmission; IMP:MGI.
 GO:0060081; P:membrane hyperpolarization; IEA:Compara.
 GO:0021554; P:optic nerve development; IEA:Compara.
 GO:0055075; P:potassium ion homeostasis; IMP:MGI.
 GO:0010107; P:potassium ion import; IEA:Compara.
 GO:0051289; P:protein homotetramerization; IEA:Compara.
 GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IMP:MGI.
 GO:0060075; P:regulation of resting membrane potential; IMP:MGI.
 GO:0051930; P:regulation of sensory perception of pain; IEA:Compara.
 GO:0009637; P:response to blue light; IEA:Compara.
 GO:0051384; P:response to glucocorticoid stimulus; IEA:Compara.
 GO:0051385; P:response to mineralocorticoid stimulus; IEA:Compara.
 GO:0007601; P:visual perception; IMP:MGI. 
Interpro
 IPR014756; Ig_E-set.
 IPR016449; K_chnl_inward-rec_Kir.
 IPR003269; K_chnl_inward-rec_Kir1.2.
 IPR013518; K_chnl_inward-rec_Kir_cyto. 
Pfam
 PF01007; IRK 
SMART
  
PROSITE
  
PRINTS
 PR01322; KIR12CHANNEL.
 PR01320; KIRCHANNEL.