| Tag | Content |
|---|
| CPLM ID | CPLM-014205 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein artemis |
Protein Synonyms/Alias | DNA cross-link repair 1C protein; SNM1-like protein |
Gene Name | Dclre1c |
Gene Synonyms/Alias | Snm1l |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 374 | PKYKPLGKLKRARTV | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments. V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends. These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively. This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation, and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC. The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint. May also be required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ (By similarity). |
Sequence Annotation | MOD_RES 650 650 Phosphoserine; by ATM (By similarity). |
Keyword | Adaptive immunity; Complete proteome; DNA damage; DNA recombination; DNA repair; Endonuclease; Exonuclease; Hydrolase; Immunity; Magnesium; Nuclease; Nucleus; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 698 AA |
Protein Sequence | MSSFQGQMEE YPTISIDRFD RENLKARAYF LSHCHKDHMK GLRAPSMKRR LECSLKVFLY 60
CSPVTKELLL TSPKYKFWEN RIIAIEIETP TQVSLVDEAS GEKEEVVVTL LPAGHCPGSV 120
MFLFQGSNGT VLYTGDFRLA KGEVSRMELL HSGGRVKDIQ SVYLDTTFCD PRFYQIPSRE 180
ECLRGVLELV RSWITRSPKH VVWLNCKAAY GYEYLFTNLS EELGVQVHVD KLDMFKNMPD 240
ILHHLTTDRN TQIHACRHPK AEEYFQWNKL PCGMASKTKT VLHTISIKPS TMWFGERTRK 300
TNVIVRTGES SYRACFSFHS SYSEIKDFLS YICPVNAYPN VIPIGLTVDK VMDFLKPLCR 360
SSQCAEPKYK PLGKLKRART VHLDSEEDDD LFDDPLLTHS RRKVPYQVTL HPEVFSMKAL 420
PLDQPELGQS PGCCKAESMP SPSLANFVDC DESNSDSEGE LETPPSLQGG LGPTTLPQQN 480
ADPDVDVPRW EVFFKRKDEI TDECLENLPS SIETGGSQSP KRFSDSPKLG SDSDGESTHI 540
SSQNSSQSTH ITDQGSQGWD SQCDTVLLSS QEKSGGDSTS LNKDTYKPKP KDSISASQIE 600
QNALCPQDTH CDLKSGAEVN GVPCIEEPDT VSGRKSSPEK TSLTSTQADS QSSSDFEIPS 660
TPEAELPKPE HLQFLYGKLA TGESIVLKKE NVHSQIFK 698 |
Gene Ontology | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0008409; F:5'-3' exonuclease activity; IEA:Compara. GO:0000014; F:single-stranded DNA specific endodeoxyribonuclease activity; IEA:Compara. GO:0030183; P:B cell differentiation; IEA:Compara. GO:0006310; P:DNA recombination; IEA:UniProtKB-KW. GO:0006302; P:double-strand break repair; IEA:Compara. GO:0090305; P:nucleic acid phosphodiester bond hydrolysis; IEA:GOC. GO:0010212; P:response to ionizing radiation; IEA:Compara. GO:0000723; P:telomere maintenance; IEA:Compara. |
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Pfam | |
SMART | |
PROSITE | |
PRINTS | |