CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016115
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 RNA-binding protein 12B-A 
Protein Synonyms/Alias
 RNA-binding motif protein 12B-A 
Gene Name
 Rbm12b1 
Gene Synonyms/Alias
 Rbm12b; Rbm12ba 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
730FDHLQGGKFDFEKYKacetylation[1]
758NLNCVSDKIIPVKISacetylation[1, 2, 3]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
  
Sequence Annotation
 DOMAIN 154 229 RRM 1.
 DOMAIN 283 359 RRM 2.
 DOMAIN 401 478 RRM 3.
 DOMAIN 760 836 RRM 4.
 MOD_RES 277 277 Phosphoserine.
 MOD_RES 279 279 Phosphoserine.
 MOD_RES 683 683 Phosphoserine (By similarity).  
Keyword
 Complete proteome; Phosphoprotein; Reference proteome; Repeat; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 836 AA 
Protein Sequence
MAVVIRLLGL PFIAGPVDIR HFFKGLTIPD GGVHIIGGKV GEAFIIFATD EDARRAISRS 60
GGFIKDSSVE LFLSSKVEMQ KTIEMKRTAR VGRGRPGSGA SGVGNVYHFS DALKEEESYS 120
GYGSSVNRDA GFHTNGTGLD LRPRKTRPLK AENPYLFLRG LPYLVNEDDV RVFFSGLCVD 180
GVILLKHHDG RNNGDAIVKF ASCVDASGGL KCHRSFMGSR FIEVMQGSEQ QWIEFGGTAT 240
EGGDTPRMRS EEHSPSRRIN GRHFRKRSHS KSPRARSRSP LGFYVHLKNL SLNTNKRDLR 300
NLFRDTDLTN DQIKFVYKDE RRTRYAFVMF KNQKDYNTAL GLHKTVLQYR PVLIDPVSRK 360
EMVRIIECYE KKRPESLEKE RPGRVSQKYS QEGFSGSGQK LCIYIRNLPF DVTKGEVQKF 420
FADFSLVEDD IYLLCDDKGV GLGEALVRFK SEEQAMKAER LNRQRFLGIE VLLRLISEEQ 480
MQEFGVKSSW LSNERTQACS RSHDGDDCSC LFDLKDPSSC SFGQSESLRY HPKDLRKMGH 540
FKHPQGYFRQ SDRRSPEDFR HSPEDYRHPW EEHTSHSREE DWRLPLEDWK WSQEDDFRQC 600
HEKDRRQLRS PWEEDFRRPS QEHFRRSYQE HIRQPPEEHF RRSREEDFRH VADEDFRQAS 660
DEDFRTSQED LRYPTDEDFR RVSVEDLREV PEKDLRLPKN FRSPGEEFWT PPDFRGQHPF 720
GNFDHLQGGK FDFEKYKFGS FPDAKVTSDL NLNCVSDKII PVKISNLPFK ANASEILDFF 780
HGYKVIPDSV SLQYNEQGLP IGEAIVAMTN YNEALAAVKD LSGRPVGPRK VKLSLL 836 
Gene Ontology
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW. 
Interpro
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 
Pfam
  
SMART
 SM00360; RRM 
PROSITE
 PS50102; RRM 
PRINTS