CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018129
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Mitochondrial antiviral-signaling protein 
Protein Synonyms/Alias
 MAVS; CARD adapter inducing interferon beta; Cardif; Interferon beta promoter stimulator protein 1; IPS-1; Virus-induced-signaling adapter; VISA 
Gene Name
 Mavs 
Gene Synonyms/Alias
 Ips1; Visa 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
7*MTFAEDKTYKYIRDubiquitination[1]
297SPRLVPVKTMSSKLPubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Required for innate immune defense against viruses. Acts downstream of DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon- independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon- dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis (By similarity). 
Sequence Annotation
 DOMAIN 10 77 CARD.
 REGION 10 77 Required for interaction with NLRX1 (By
 REGION 143 147 Interaction with TRAF2 (By similarity).
 REGION 153 158 Interaction with TRAF6 1 (By similarity).
 REGION 431 436 Interaction with TRAF6 2 (By similarity).
 MOD_RES 147 147 Phosphothreonine.
 MOD_RES 152 152 Phosphoserine.
 MOD_RES 157 157 Phosphoserine.
 MOD_RES 220 220 Phosphoserine (By similarity).
 MOD_RES 251 251 Phosphoserine (By similarity).
 MOD_RES 256 256 Phosphoserine (By similarity).
 MOD_RES 309 309 Phosphoserine.
 MOD_RES 310 310 Phosphothreonine.  
Keyword
 3D-structure; Antiviral defense; Complete proteome; Immunity; Innate immunity; Membrane; Mitochondrion; Mitochondrion outer membrane; Peroxisome; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 503 AA 
Protein Sequence
MTFAEDKTYK YIRDNHSKFC CVDVLEILPY LSCLTASDQD RLRASYRQIG NRDTLWGLFN 60
NLQRRPGWVE VFIRALQICE LPGLADQVTR VYQSYLPPGT SLRSLEPLQL PDFPAAVSGP 120
SAFAPGHNIP DHGLRETPSC PKPVQDTQPP ESPVENSEQL LQTNSGAVAR MSGGSLIPSP 180
NQQALSPQPS REHQEQEPEL GGAHAANVAS VPIATYGPVS PTVSFQPLPR TALRTNLLSG 240
VTVSALSADT SLSSSSTGSA FAKGAGDQAK AATCFSTTLT NSVTTSSVPS PRLVPVKTMS 300
SKLPLSSKST AAMTSTVLTN TAPSKLPSNS VYAGTVPSRV PASVAKAPAN TIPPERNSKQ 360
AKETPEGPAT KVTTGGNQTG PNSSIRSLHS GPEMSKPGVL VSQLDEPFSA CSVDLAISPS 420
SSLVSEPNHG PEENEYSSFR IQVDESPSAD LLGSPEPLAT QQPQEEEEHC ASSMPWAKWL 480
GATSALLAVF LAVMLYRSRR LAQ 503 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005741; C:mitochondrial outer membrane; TAS:Reactome.
 GO:0005778; C:peroxisomal membrane; IEA:Compara.
 GO:0005777; C:peroxisome; IDA:UniProtKB.
 GO:0004871; F:signal transducer activity; IMP:UniProtKB.
 GO:0071360; P:cellular response to exogenous dsRNA; IEA:Compara.
 GO:0042742; P:defense response to bacterium; ISS:UniProtKB.
 GO:0045087; P:innate immune response; ISS:UniProtKB.
 GO:0045071; P:negative regulation of viral genome replication; IMP:UniProtKB.
 GO:0071651; P:positive regulation of chemokine (C-C motif) ligand 5 production; IEA:Compara.
 GO:0002230; P:positive regulation of defense response to virus by host; ISS:UniProtKB.
 GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IEA:Compara.
 GO:0032727; P:positive regulation of interferon-alpha production; ISS:UniProtKB.
 GO:0032728; P:positive regulation of interferon-beta production; ISS:UniProtKB.
 GO:0032757; P:positive regulation of interleukin-8 production; IEA:Compara.
 GO:0071660; P:positive regulation of IP-10 production; IEA:Compara.
 GO:0033160; P:positive regulation of protein import into nucleus, translocation; IEA:Compara.
 GO:0001934; P:positive regulation of protein phosphorylation; IEA:Compara.
 GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0042993; P:positive regulation of transcription factor import into nucleus; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0032760; P:positive regulation of tumor necrosis factor production; IEA:Compara.
 GO:0060340; P:positive regulation of type I interferon-mediated signaling pathway; IEA:Compara.
 GO:1900063; P:regulation of peroxisome organization; IMP:UniProtKB.
 GO:0039529; P:RIG-I signaling pathway; IGI:MGI. 
Interpro
 IPR026148; Mt_antiviral_sig_pro. 
Pfam
  
SMART
  
PROSITE
 PS50209; CARD 
PRINTS