CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033656
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Rho GTPase-activating protein 23 
Protein Synonyms/Alias
  
Gene Name
 ARHGAP23 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
580EDADAPSKRHSTSDLubiquitination[1, 2]
730ANQALISKKLNDYRKubiquitination[3]
731NQALISKKLNDYRKVubiquitination[2]
760SRGLGGLKSEFLKQSubiquitination[2]
782QDLPAGSKDDSAAAPubiquitination[1]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; GTPase activation; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1397 AA 
Protein Sequence
MDTIFVKNVK EDGPAHRAGL RTGDRLVKVN GESVIGKTYS QVIALIQNSD DTLELSIMPK 60
DEDILQLAYS QDAYLKGNEP YSGEARSIPE PPPICYPRKT YAPPARASTR ATMVPEPTSA 120
LPSDPRSPAA WSDPGLRVPP AARAHLDNSS LGMSQPRPSP GAFPHLSSEP RTPRAFPEPG 180
SRVPPSRLEC QQALSHWLSN QVPRRAGERR CPAMAPRARS ASQDRLEEVA APRPWPCSTS 240
QDALSQLGQE GWHRARSDDY LSRATRSAEA LGPGALVSPR FERCGWASQR SSARTPACPT 300
RDLPGPQAPP PSGLQGLDDL GYIGYRSYSP SFQRRTGLLH ALSFRDSPFG GLPTFNLAQS 360
PASFPPEASE PPRVVRPEPS TRALEPPAED RGDEVVLRQK PPTGRKVQLT PARQMNLGFG 420
DESPEPEASG RGERLGRKVA PLATTEDSLA SIPFIDEPTS PSIDLQAKHV PASAVVSSAM 480
NSAPVLGTSP SSPTFTFTLG RHYSQDCSSI KAGRRSSYLL AITTERSKSC DDGLNTFRDE 540
GRVLRRLPNR IPSLRMLRSF FTDGSLDSWG TSEDADAPSK RHSTSDLSDA TFSDIRREGW 600
LYYKQILTKK GKKAGSGLRQ WKRVYAALRA RSLSLSKERR EPGPAAAGAA AAGAGEDEAA 660
PVCIGSCLVD ISYSETKRRH VFRLTTADFC EYLFQAEDRD DMLGWIRAIR ENSRAEGEDP 720
GCANQALISK KLNDYRKVSH SSGPKADSSP KGSRGLGGLK SEFLKQSAAR GLRTQDLPAG 780
SKDDSAAAPK TPWGINIIKK NKKAAPRAFG VRLEECQPAT ENQRVPLIVA ACCRIVEARG 840
LESTGIYRVP GNNAVVSSLQ EQLNRGPGDI NLQDERWQDL NVISSLLKSF FRKLPEPLFT 900
DDKYNDFIEA NRIEDARERM RTLRKLIRDL PGHYYETLKF LVGHLKTIAD HSEKNKMEPR 960
NLALVFGPTL VRTSEDNMTD MVTHMPDRYK IVETLIQHSD WFFSDEEDKG ERTPVGDKEP 1020
QAVPNIEYLL PNIGRTVPPG DPGSDSTTCS SAKSKGSWAP KKEPYAREML AISFISAVNR 1080
KRKKRREARG LGSSTDDDSE QEAHKPGAGA TAPGTQERPQ GPLPGAVAPE APGRLSPPAA 1140
PEERPAADTR SIVSGYSTLS TMDRSVCSGA SGRRAGAGDE ADDERSELSH VETDTEGAAG 1200
AGPGGRLTRR PSFSSHHLMP CDTLARRRLA RGRPDGEGAG RGGPRAPEPP GSASSSSQES 1260
LRPPAAALAS RPSRMEALRL RLRGTADDML AVRLRRPLSP ETRRRRSSWR RHTVVVQSPL 1320
TDLNFNEWKE LGGGGPPEPA GARAHSDNKD SGLSSLESTK ARAPSSAASQ PPAPGDTGSL 1380
QSQPPRRSAA SRLHQCL 1397 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0043547; P:positive regulation of GTPase activity; IEA:GOC.
 GO:0007165; P:signal transduction; IEA:InterPro. 
Interpro
 IPR001478; PDZ.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR008936; Rho_GTPase_activation_prot.
 IPR000198; RhoGAP_dom. 
Pfam
 PF00595; PDZ
 PF00169; PH
 PF00620; RhoGAP 
SMART
 SM00228; PDZ
 SM00233; PH
 SM00324; RhoGAP 
PROSITE
 PS50106; PDZ
 PS50003; PH_DOMAIN
 PS50238; RHOGAP 
PRINTS